U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Klhl40 kelch-like family member 40 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316088, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klhl40provided by RGD
    Official Full Name
    kelch-like family member 40provided by RGD
    Primary source
    RGD:1305368
    See related
    EnsemblRapid:ENSRNOG00000019390 AllianceGenome:RGD:1305368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kbtbd5
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of protein metabolic process; and skeletal muscle fiber development. Predicted to act upstream of or within skeletal muscle fiber differentiation. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in A band and I band. Human ortholog(s) of this gene implicated in nemaline myopathy 8. Orthologous to human KLHL40 (kelch like family member 40). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 378.2), Adrenal (RPKM 53.3) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Klhl40 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130318793..130324309)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121441285..121446801)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130416265..130421871)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene natural killer cell triggering receptor Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene hedgehog acyltransferase-like Neighboring gene coiled-coil domain containing 13 Neighboring gene HIG1 hypoxia inducible domain family, member 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of protein ubiquitination  
    acts_upstream_of_or_within negative regulation of protein ubiquitination  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein ubiquitination  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process  
    acts_upstream_of protein ubiquitination  
    involved_in skeletal muscle fiber development  
    acts_upstream_of_or_within skeletal muscle fiber development  
    involved_in skeletal muscle fiber development  
    acts_upstream_of_or_within skeletal muscle fiber differentiation  
    involved_in skeletal muscle fiber differentiation  
    Component Evidence Code Pubs
    is_active_in A band  
    located_in A band  
    part_of Cul3-RING ubiquitin ligase complex  
    part_of Cul3-RING ubiquitin ligase complex  
    is_active_in I band  
    located_in I band  
    is_active_in cytoplasm  
    located_in cytoplasm  

    General protein information

    Preferred Names
    kelch-like protein 40
    Names
    kelch repeat and BTB (POZ) domain containing 5
    kelch repeat and BTB domain-containing protein 5
    kelch-like 40

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108195.2NP_001101665.2  kelch-like protein 40

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I459, D4AA43
      Related
      ENSRNOP00000026234.6, ENSRNOT00000026234.7
      Conserved Domains (3) summary
      PHA03098
      Location:47594
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:402448
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:6137
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      130318793..130324309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.