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    Rtca RNA 3'-terminal phosphate cyclase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295395, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rtcaprovided by RGD
    Official Full Name
    RNA 3'-terminal phosphate cyclaseprovided by RGD
    Primary source
    RGD:1303111
    See related
    EnsemblRapid:ENSRNOG00000014575 AllianceGenome:RGD:1303111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rtcd1
    Summary
    Predicted to enable RNA-3'-phosphate cyclase activity. Predicted to be involved in negative regulation of optical nerve axon regeneration. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human RTCA (RNA 3'-terminal phosphate cyclase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 134.0), Adrenal (RPKM 120.9) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rtca in Genome Data Viewer
    Location:
    2q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (207140090..207161366, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204455175..204476450, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219537213..219558489, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485677 Neighboring gene cell division cycle 14A Neighboring gene uncharacterized LOC120100925 Neighboring gene uncharacterized LOC134485678 Neighboring gene dihydrolipoamide branched chain transacylase E2 Neighboring gene leucine rich repeat containing 39 Neighboring gene tRNA methyltransferase 13 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC94866

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA-3'-phosphate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA-3'-phosphate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of optical nerve axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RNA 3'-terminal phosphate cyclase
    Names
    RNA terminal phosphate cyclase domain 1
    NP_001004227.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004227.1NP_001004227.1  RNA 3'-terminal phosphate cyclase

      See identical proteins and their annotated locations for NP_001004227.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079374
      UniProtKB/TrEMBL
      A0A8I6AF49, F6PU86, Q68FS8
      Related
      ENSRNOP00000020149.5, ENSRNOT00000020149.7
      Conserved Domains (1) summary
      pfam01137
      Location:12338
      RTC; RNA 3'-terminal phosphate cyclase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      207140090..207161366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)