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    Flt3 Fms related receptor tyrosine kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140635, updated on 27-Dec-2024

    Summary

    Official Symbol
    Flt3provided by RGD
    Official Full Name
    Fms related receptor tyrosine kinase 3provided by RGD
    Primary source
    RGD:61308
    See related
    EnsemblRapid:ENSRNOG00000054764 AllianceGenome:RGD:61308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables nuclear glucocorticoid receptor binding activity. Involved in cellular response to glucocorticoid stimulus and liver regeneration. Part of protein-containing complex. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 69.2), Brain (RPKM 39.3) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Flt3 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (12660035..12735584)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (7623930..7699474)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (9360439..9437004)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene uncharacterized LOC134481260 Neighboring gene ribosomal protein L18A, pseudogene 2 Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase Neighboring gene caudal type homeo box 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables cytokine receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables growth factor binding  
    enables hepatocyte growth factor receptor activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables metal ion binding  
    enables nuclear glucocorticoid receptor binding PubMed 
    enables phosphatidylinositol 3-kinase binding  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables protein-containing complex binding PubMed 
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane-ephrin receptor activity  
    enables ubiquitin protein ligase binding  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 26
    Items 1 - 25 of 54
    Process Evidence Code Pubs
    involved_in B cell differentiation  
    involved_in B cell differentiation  
    involved_in Kit signaling pathway  
    acts_upstream_of_or_within antigen processing and presentation  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    acts_upstream_of cell population proliferation  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cellular response to cytokine stimulus  
    involved_in cellular response to glucocorticoid stimulus PubMed 
    acts_upstream_of_or_within cellular response to virus  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in common myeloid progenitor cell proliferation  
    involved_in cytokine-mediated signaling pathway  
    involved_in cytokine-mediated signaling pathway  
    involved_in dendritic cell differentiation  
    acts_upstream_of_or_within dendritic cell homeostasis  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within hemopoiesis  
    involved_in hepatocyte growth factor receptor signaling pathway  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in leukocyte homeostasis  
    involved_in liver regeneration PubMed 
    acts_upstream_of_or_within lymph node development  
    acts_upstream_of_or_within lymphocyte differentiation  
    involved_in lymphocyte proliferation  
    acts_upstream_of_or_within lymphoid progenitor cell differentiation  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in multicellular organism development  
    acts_upstream_of_or_within myeloid progenitor cell differentiation  
    involved_in myeloid progenitor cell differentiation  
    acts_upstream_of_or_within negative regulation of B cell differentiation  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of interleukin-6 production  
    acts_upstream_of_or_within negative regulation of tumor necrosis factor production  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    acts_upstream_of_or_within positive regulation of interferon-alpha production  
    acts_upstream_of_or_within positive regulation of interleukin-12 production  
    acts_upstream_of_or_within positive regulation of multicellular organism growth  
    acts_upstream_of_or_within positive regulation of protein phosphorylation  
    acts_upstream_of_or_within positive regulation of type II interferon production  
    acts_upstream_of_or_within post-embryonic development  
    acts_upstream_of_or_within pro-B cell differentiation  
    involved_in pro-B cell differentiation  
    acts_upstream_of_or_within pro-T cell differentiation  
    acts_upstream_of_or_within protein autophosphorylation  
    acts_upstream_of protein phosphorylation  
    acts_upstream_of_or_within spleen development  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 54
    Component Evidence Code Pubs
    located_in cell surface  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in external side of plasma membrane  
    is_active_in plasma membrane  
    part_of protein-containing complex PubMed 
    part_of receptor complex  

    General protein information

    Preferred Names
    receptor-type tyrosine-protein kinase FLT3
    Names
    FL cytokine receptor
    FMS-like tyrosine kinase 3
    fms-related tyrosine kinase 3
    NP_001402681.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415752.1 → NP_001402681.1  receptor-type tyrosine-protein kinase FLT3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A0G2JW59, A6K1A4
      Related
      ENSRNOP00000069753.3, ENSRNOT00000088957.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      12660035..12735584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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