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    Use1 unconventional SNARE in the ER 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Use1provided by RGD
    Official Full Name
    unconventional SNARE in the ER 1provided by RGD
    Primary source
    RGD:1306660
    See related
    EnsemblRapid:ENSRNOG00000016619 AllianceGenome:RGD:1306660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306660
    Summary
    Predicted to enable SNAP receptor activity. Predicted to be involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Located in COPI-coated vesicle. Part of SNARE complex. Orthologous to human USE1 (unconventional SNARE in the ER 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 168.4), Heart (RPKM 165.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Use1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18069118..18075816)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18038284..18041826)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19762202..19765781)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene HAUS augmin-like complex, subunit 8 Neighboring gene myosin IXb Neighboring gene occludin/ELL domain containing 1 Neighboring gene nuclear receptor subfamily 2, group F, member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Members of a mammalian SNARE complex interact in the endoplasmic reticulum in vivo and are found in COPI vesicles. Verrier SE, et al. Eur J Cell Biol, 2008 Nov. PMID 18834646
    2. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Uemura T, et al. Mol Cell Biol, 2009 Apr. PMID 19188447, Free PMC Article
    3. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. Hirose H, et al. EMBO J, 2004 Mar 24. PMID 15029241, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in COPI-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vesicle transport protein USE1
    Names
    unconventional SNARE in the ER 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169100.1 → NP_001162571.1  vesicle transport protein USE1

      Status: VALIDATED

      Source sequence(s)
      BC158812, JAXUCZ010000016
      UniProtKB/TrEMBL
      A6K9S0
      Related
      ENSRNOP00000022650.8, ENSRNOT00000022650.9
      Conserved Domains (1) summary
      pfam09753
      Location:17 → 266
      Use1; Membrane fusion protein Use1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18069118..18075816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252855.5 → XP_006252917.1  vesicle transport protein USE1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1D9, A6K9S0
      Conserved Domains (1) summary
      pfam09753
      Location:17 → 267
      Use1; Membrane fusion protein Use1
    Nucleotide Protein Strain
    Heading Accession and Version

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