Fetub fetuin B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fetubprovided by RGD
Official Full Name: fetuin Bprovided by RGD
Primary source: RGD:69293
See related: EnsemblRapid:ENSRNOG00000001806 AllianceGenome:RGD:69293
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fet; Pp63; IRL685
Summary: Predicted to enable metalloendopeptidase inhibitor activity. Predicted to be involved in binding activity of sperm to zona pellucida and negative regulation of endopeptidase activity. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Orthologous to human FETUB (fetuin B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 4654.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (91586750..91599789, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (78082158..78093022, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (81648890..81660472, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pancreastatin deteriorates hepatic lipid metabolism via elevating fetuin B in ovariectomized rats.
Title: Pancreastatin deteriorates hepatic lipid metabolism via elevating fetuin B in ovariectomized rats.
fetuin inhibits calcium phosphate precipitation and forms a fetuin-mineral complex
Title: The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fetuin-B

Names: fetuin beta; fetuin phosphoprotein; fetuin-like protein IRL685

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309522.1 → NP_001296451.1 fetuin-B isoform 1 precursor

See identical proteins and their annotated locations for NP_001296451.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC070508, JAXUCZ010000011

UniProtKB/TrEMBL

A6JS44, Q6IRS6

Related

ENSRNOP00000051504.3, ENSRNOT00000048739.6

Conserved Domains (3) summary

pfam00031
Location:172 → 261

Cystatin; Cystatin domain

pfam12238
Location:290 → 361

MSA-2c; Merozoite surface antigen 2c

cl09238
Location:49 → 137

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
NM_053348.2 → NP_445800.2 fetuin-B precursor

See identical proteins and their annotated locations for NP_445800.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different 5' structure, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compaerd to isoform 1.

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

F1LN83, Q9QX79

UniProtKB/TrEMBL

A0A8I5ZW28

Related

ENSRNOP00000082888.1, ENSRNOT00000100999.2

Conserved Domains (3) summary

pfam00031
Location:157 → 246

Cystatin; Cystatin domain

pfam12238
Location:275 → 346

MSA-2c; Merozoite surface antigen 2c

cl09238
Location:34 → 122

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.