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    Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pik3r3provided by RGD
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 3provided by RGD
    Primary source
    RGD:621042
    See related
    EnsemblRapid:ENSRNOG00000000145 AllianceGenome:RGD:621042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; insulin receptor signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 170.7), Lung (RPKM 127.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pik3r3 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134936790..135009303)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129700925..129772591)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135069972..135145633)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 1 Neighboring gene PIK3R3 upstream open reading frame Neighboring gene uncharacterized LOC120103122 Neighboring gene transfer RNA proline (anticodon AGG) 7 Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of PI3K regulatory subunit p55γ as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation. Li G, et al. Cardiovasc Res, 2015 Jan 1. PMID 25388664
    2. PIK3R3 induces epithelial-to-mesenchymal transition and promotes metastasis in colorectal cancer. Wang G, et al. Mol Cancer Ther, 2014 Jul. PMID 24837077
    3. Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. Nowakowska-Zajdel E, et al. Int J Immunopathol Pharmacol, 2011 Jul-Sep. PMID 21978709
    4. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. Inukai K, et al. J Biol Chem, 1996 Mar 8. PMID 8621382
    5. MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3. Zhu Y, et al. Oncol Rep, 2017 Apr. PMID 28260020

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Western blot and mRNA analyses showed that p55gamma expression declined in balloon-injured carotid arteries.
      Title: Identification of PI3K regulatory subunit p55γ as a novel inhibitor of vascular smooth muscle cell proliferation and neointimal formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit gamma
    Names
    PI3-kinase p85 subunit gamma
    PI3-kinase regulatory subunit gamma
    PI3-kinase subunit p55-gamma
    PI3K regulatory subunit gamma
    p55PIK
    phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
    phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
    phosphatidylinositol 3-kinase p55 subunit
    phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
    ptdIns-3-kinase p85-gamma
    ptdIns-3-kinase regulatory subunit gamma
    ptdIns-3-kinase regulatory subunit p55-gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429916.1 → NP_001416845.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q63789
      UniProtKB/TrEMBL
      A6JZ71, G3V605

    2. NM_001429917.1 → NP_001416846.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q63789
      UniProtKB/TrEMBL
      A6JZ71, G3V605

    3. NM_001429918.1 → NP_001416847.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q63789
      UniProtKB/TrEMBL
      A6JZ71, G3V605

    4. NM_001429919.1 → NP_001416848.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q63789

    5. NM_001429920.1 → NP_001416849.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q63789

    6. NM_001429921.1 → NP_001416850.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    7. NM_001429922.1 → NP_001416851.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    8. NM_001429923.1 → NP_001416852.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    9. NM_022213.3 → NP_071549.2  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q63789
      UniProtKB/TrEMBL
      A6JZ71, G3V605
      Related
      ENSRNOP00000000157.2, ENSRNOT00000000157.5
      Conserved Domains (3) summary
      cd09930
      Location:351 → 454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59 → 167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172 → 332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      134936790..135009303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110699.2 → XP_038966627.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

      Conserved Domains (3) summary
      cd09930
      Location:351 → 454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59 → 167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172 → 332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. XM_006238714.4 → XP_006238776.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

      Conserved Domains (3) summary
      cd09930
      Location:351 → 454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59 → 167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172 → 332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. XM_039110698.2 → XP_038966626.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

      Conserved Domains (3) summary
      cd09930
      Location:351 → 454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59 → 167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172 → 332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63789.1 GenPept UniProtKB/Swiss-Prot:Q63789

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