Fut4 fucosyltransferase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fut4provided by RGD
Official Full Name: fucosyltransferase 4provided by RGD
Primary source: RGD:619954
See related: EnsemblRapid:ENSRNOG00000009157 AllianceGenome:RGD:619954
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fuct
Summary: Enables alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in several processes, including Lewis x epitope biosynthetic process; protein glycosylation; and regulation of leukocyte migration. Predicted to be located in cell periphery; cell surface; and trans-Golgi network. Orthologous to human FUT4 (fucosyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 8q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (19868178..19872139, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (11586721..11590682, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (13258768..13262729, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that using a rat model of endometriosis, ectopic endometrium showed significantly higher Oct4 (POU5F1), and SSEA1, but similar Thy1 gene expression to that of control endometrium. This indicates increased transition from somatic to pluripotent cell states in ectopic endometrium which may play a role in endometriosis pathogenesis.
Title: Stem Cell Markers Describe a Transition From Somatic to Pluripotent Cell States in a Rat Model of Endometriosis.
The carbohydrate Le(x) epitope has been found in the tetanus neurotoxin insensitive vesicle-associated membrane protein (TI-VAMP) compartment of rat hippocampus neurons in culture, at 7 days in vitro, when neurite extension is abundant.
Title: Subcellular localization of the carbohydrate Lewis(x) adhesion structure in hippocampus cell cultures.

Submit: New GeneRIF Correction

General gene information

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Markers

AI237192 (e-PCR)
- UniSTS:261649

BF412716 (e-PCR)
- UniSTS:248290

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-(1->3)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->3)-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Lewis x epitope biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in Lewis x epitope biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycosphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycosphingolipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte migration into lymph node	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte migration into lymph node	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte migration into lymph node	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligosaccharide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of leukocyte tethering or rolling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: alpha-(1,3)-fucosyltransferase 4

Names: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; alpha 1,3-fucosyltransferase Fuc-T (similar to mouse Fut4); alpha 13-fucosyltransferase Fuc-T (similar to mouse Fut4); fuc-TIV; fucT-IV; fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); fucosyltransferase IV; galactoside 3-L-fucosyltransferase

NP_071555.3

EC 2.4.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022219.3 → NP_071555.3 alpha-(1,3)-fucosyltransferase 4

See identical proteins and their annotated locations for NP_071555.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6JN98, G3V757, Q99N88

Related

ENSRNOP00000012176.1, ENSRNOT00000012176.5

Conserved Domains (2) summary

pfam00852
Location:256 → 428

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:87 → 234

Glyco_tran_10_N; Fucosyltransferase, N-terminal