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    Gsk3b glycogen synthase kinase 3 beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84027, updated on 27-Dec-2024

    Summary

    Official Symbol
    Gsk3bprovided by RGD
    Official Full Name
    glycogen synthase kinase 3 betaprovided by RGD
    Primary source
    RGD:70982
    See related
    EnsemblRapid:ENSRNOG00000002833 AllianceGenome:RGD:70982
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including ATP binding activity; protein serine/threonine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of neuron projection development; and regulation of synapse organization. Located in several cellular components, including axon; dendritic spine; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); depressive disorder; diabetic encephalopathy; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 86.7), Adrenal (RPKM 86.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gsk3b in Genome Data Viewer
    Location:
    11q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (76004502..76154665, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (62498997..62648665, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (65060884..65208842, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase copper chaperone COX17 Neighboring gene cilia and flagella associated protein 91 Neighboring gene nuclear receptor subfamily 1, group I, member 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene G protein-coupled receptor 156

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 62
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables NF-kappaB binding  
    enables NF-kappaB binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables beta-catenin binding  
    enables beta-catenin binding  
    enables beta-catenin binding  
    enables dynactin binding  
    enables dynactin binding  
    enables dynein complex binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables integrin binding PubMed 
    enables ionotropic glutamate receptor binding PubMed 
    enables kinase activity PubMed 
    enables kinase activity  
    enables kinase activity  
    enables p53 binding  
    enables p53 binding  
    enables protease binding  
    enables protease binding  
    enables protein binding PubMed 
    enables protein kinase A catalytic subunit binding  
    enables protein kinase A catalytic subunit binding  
    enables protein kinase activity  
    enables protein kinase activity  
    enables protein kinase binding PubMed 
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase binding PubMed 
    enables ribosomal protein S6 kinase activity  
    enables scaffold protein binding  
    enables tau protein binding PubMed 
    enables tau-protein kinase activity  
    enables tau-protein kinase activity PubMed 
    enables tau-protein kinase activity  
    enables tau-protein kinase activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 62
    Items 1 - 25 of 209
    Process Evidence Code Pubs
    involved_in ER overload response  
    acts_upstream_of_or_within ER overload response  
    involved_in Wnt signaling pathway  
    acts_upstream_of_or_within Wnt signaling pathway  
    acts_upstream_of_or_within animal organ morphogenesis  
    acts_upstream_of_positive_effect autosome genomic imprinting  
    acts_upstream_of axon extension  
    acts_upstream_of_or_within axonogenesis  
    involved_in bone remodeling PubMed 
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of_or_within canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in cell differentiation  
    involved_in cell differentiation  
    involved_in cell growth involved in cardiac muscle cell development PubMed 
    acts_upstream_of_or_within cell migration  
    involved_in cellular response to amyloid-beta PubMed 
    involved_in cellular response to dopamine PubMed 
    involved_in cellular response to erythropoietin PubMed 
    involved_in cellular response to glucocorticoid stimulus  
    acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus  
    involved_in cellular response to hydrogen peroxide PubMed 
    involved_in cellular response to interleukin-3  
    involved_in cellular response to interleukin-3  
    involved_in cellular response to iron(II) ion PubMed 
    involved_in cellular response to lithium ion PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to retinoic acid  
    involved_in cellular response to retinoic acid  
    involved_in circadian rhythm  
    involved_in circadian rhythm  
    involved_in epithelial to mesenchymal transition  
    involved_in epithelial to mesenchymal transition  
    involved_in epithelial to mesenchymal transition  
    involved_in establishment of cell polarity PubMed 
    involved_in establishment of cell polarity PubMed 
    involved_in establishment or maintenance of cell polarity PubMed 
    involved_in extrinsic apoptotic signaling pathway  
    involved_in extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in extrinsic apoptotic signaling pathway in absence of ligand  
    acts_upstream_of_or_within fat cell differentiation  
    involved_in glycogen metabolic process  
    involved_in glycogen metabolic process  
    involved_in hepatic stellate cell activation PubMed 
    involved_in hepatocyte apoptotic process PubMed 
    involved_in hippocampus development  
    involved_in hippocampus development  
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    acts_upstream_of_or_within intracellular signal transduction  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
    involved_in maintenance of cell polarity PubMed 
    involved_in meiosis I  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization  
    acts_upstream_of_or_within myoblast fusion  
    acts_upstream_of_or_within myotube differentiation  
    involved_in negative regulation of MAP kinase activity PubMed 
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of TORC2 signaling  
    involved_in negative regulation of TORC2 signaling  
    acts_upstream_of_or_within negative regulation of apoptotic process  
    involved_in negative regulation of calcineurin-NFAT signaling cascade  
    involved_in negative regulation of calcineurin-NFAT signaling cascade  
    involved_in negative regulation of calcineurin-NFAT signaling cascade  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within negative regulation of cardiac muscle hypertrophy  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of dendrite development PubMed 
    involved_in negative regulation of dendrite morphogenesis PubMed 
    involved_in negative regulation of developmental process  
    involved_in negative regulation of dopaminergic neuron differentiation PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition  
    involved_in negative regulation of epithelial to mesenchymal transition  
    involved_in negative regulation of epithelial to mesenchymal transition  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in negative regulation of gene expression  
    acts_upstream_of negative regulation of gene expression  
    involved_in negative regulation of glycogen biosynthetic process  
    involved_in negative regulation of insulin receptor signaling pathway PubMed 
    involved_in negative regulation of mesenchymal stem cell differentiation  
    involved_in negative regulation of mesenchymal stem cell differentiation  
    acts_upstream_of_or_within negative regulation of neuron maturation  
    involved_in negative regulation of neuron migration PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development  
    involved_in negative regulation of nitric-oxide synthase activity PubMed 
    involved_in negative regulation of osteoblast differentiation  
    involved_in negative regulation of osteoblast differentiation  
    involved_in negative regulation of protein acetylation PubMed 
    involved_in negative regulation of protein localization to centrosome  
    involved_in negative regulation of protein localization to nucleus PubMed 
    involved_in negative regulation of protein-containing complex assembly  
    involved_in negative regulation of protein-containing complex assembly  
    involved_in negative regulation of signal transduction  
    involved_in negative regulation of smooth muscle cell apoptotic process PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction PubMed 
    involved_in nervous system development  
    involved_in neuron projection development  
    involved_in neuron projection development  
    involved_in neuron projection development  
    involved_in neuron projection organization PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-threonine phosphorylation  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphorylation  
    involved_in positive regulation of DNA biosynthetic process PubMed 
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    acts_upstream_of_or_within positive regulation of axon extension  
    involved_in positive regulation of cardiac muscle cell differentiation  
    involved_in positive regulation of cell differentiation  
    involved_in positive regulation of cell differentiation  
    involved_in positive regulation of cell-matrix adhesion  
    involved_in positive regulation of cell-matrix adhesion  
    involved_in positive regulation of cilium assembly  
    involved_in positive regulation of cilium assembly  
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of gene expression  
    acts_upstream_of positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of mitochondrial membrane potential PubMed 
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of osteoblast proliferation PubMed 
    involved_in positive regulation of osteoclast differentiation PubMed 
    involved_in positive regulation of osteoclast proliferation PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-threonine phosphorylation  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein catabolic process PubMed 
    involved_in positive regulation of protein export from nucleus  
    acts_upstream_of_or_within positive regulation of protein export from nucleus  
    involved_in positive regulation of protein localization to centrosome  
    involved_in positive regulation of protein localization to centrosome  
    involved_in positive regulation of protein localization to cilium  
    involved_in positive regulation of protein localization to cilium  
    involved_in positive regulation of protein ubiquitination  
    involved_in positive regulation of protein ubiquitination  
    involved_in positive regulation of protein-containing complex assembly  
    involved_in positive regulation of protein-containing complex assembly  
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of stem cell differentiation  
    involved_in positive regulation of synaptic assembly at neuromuscular junction PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in protein autophosphorylation  
    acts_upstream_of_or_within protein export from nucleus  
    acts_upstream_of_or_within protein localization to microtubule  
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    acts_upstream_of_or_within re-entry into mitotic cell cycle  
    involved_in regulation of apoptotic process  
    involved_in regulation of axon extension PubMed 
    involved_in regulation of axonogenesis PubMed 
    acts_upstream_of_or_within regulation of cell growth  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of dendrite morphogenesis PubMed 
    involved_in regulation of long-term synaptic potentiation  
    involved_in regulation of long-term synaptic potentiation  
    involved_in regulation of microtubule anchoring at centrosome  
    involved_in regulation of microtubule anchoring at centrosome  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of microtubule cytoskeleton organization PubMed 
    involved_in regulation of microtubule-based process  
    involved_in regulation of microtubule-based process  
    involved_in regulation of modification of postsynaptic structure PubMed 
    involved_in regulation of modification of postsynaptic structure PubMed 
    involved_in regulation of neuron projection development  
    acts_upstream_of_or_within regulation of neuron projection development  
    involved_in regulation of neuronal synaptic plasticity PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of osteoblast differentiation PubMed 
    involved_in regulation of protein export from nucleus  
    involved_in response to L-glutamate PubMed 
    involved_in response to activity PubMed 
    involved_in response to angiotensin PubMed 
    involved_in response to epinephrine PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to insulin PubMed 
    involved_in response to insulin-like growth factor stimulus PubMed 
    involved_in response to ultrasound PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to zinc ion PubMed 
    involved_in rhythmic process  
    acts_upstream_of stem cell differentiation  
    involved_in superior temporal gyrus development  
    involved_in superior temporal gyrus development  
    acts_upstream_of transcription by RNA polymerase II  
    Items 1 - 25 of 209
    Items 1 - 20 of 46
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    part_of Wnt signalosome  
    is_active_in axon  
    located_in axon PubMed 
    part_of beta-catenin destruction complex  
    part_of beta-catenin destruction complex PubMed 
    part_of beta-catenin destruction complex  
    part_of beta-catenin destruction complex  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in dendritic shaft  
    located_in dendritic spine PubMed 
    is_active_in glutamatergic synapse  
    is_active_in glutamatergic synapse PubMed 
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in growth cone  
    is_active_in meiotic spindle  
    located_in membrane PubMed 
    located_in microtubule PubMed 
    located_in mitochondrion  
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density  
    located_in postsynaptic density  
    located_in presynapse  
    part_of protein-containing complex PubMed 
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 46

    General protein information

    Preferred Names
    glycogen synthase kinase-3 beta
    Names
    FA
    GSK-3 beta
    factor A
    serine/threonine-protein kinase GSK3B
    NP_114469.1
    XP_006248435.1
    XP_006248437.1
    XP_038944596.1
    XP_038944597.1
    XP_063126861.1
    XP_063126862.1
    XP_063126863.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032080.1NP_114469.1  glycogen synthase kinase-3 beta

      See identical proteins and their annotated locations for NP_114469.1

      Status: PROVISIONAL

      Source sequence(s)
      X73653
      UniProtKB/Swiss-Prot
      P18266
      UniProtKB/TrEMBL
      A6IR80
      Conserved Domains (1) summary
      cd14137
      Location:51343
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      76004502..76154665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248373.5XP_006248435.1  glycogen synthase kinase-3 beta isoform X1

      UniProtKB/Swiss-Prot
      P18266
      UniProtKB/TrEMBL
      A0A0G2JSH4
      Related
      ENSRNOP00000003867.4, ENSRNOT00000003867.8
      Conserved Domains (2) summary
      cd14137
      Location:51356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
      pfam00069
      Location:56353
      Pkinase; Protein kinase domain
    2. XM_039088669.2XP_038944597.1  glycogen synthase kinase-3 beta isoform X7

      Conserved Domains (1) summary
      cd14137
      Location:1256
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    3. XM_039088668.1XP_038944596.1  glycogen synthase kinase-3 beta isoform X4

      UniProtKB/Swiss-Prot
      P18266
      Conserved Domains (1) summary
      cd14137
      Location:31336
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    4. XM_063270793.1XP_063126863.1  glycogen synthase kinase-3 beta isoform X6

      UniProtKB/Swiss-Prot
      P18266
    5. XM_063270791.1XP_063126861.1  glycogen synthase kinase-3 beta isoform X2

      UniProtKB/TrEMBL
      A0A0G2KB98, A0A8I6GL38
      Related
      ENSRNOP00000075708.1, ENSRNOT00000077612.3
    6. XM_006248375.5XP_006248437.1  glycogen synthase kinase-3 beta isoform X3

      UniProtKB/TrEMBL
      A0A8I6GL38
      Conserved Domains (2) summary
      cd14137
      Location:51356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
      pfam00069
      Location:56353
      Pkinase; Protein kinase domain
    7. XM_063270792.1XP_063126862.1  glycogen synthase kinase-3 beta isoform X5

      UniProtKB/TrEMBL
      A0A8I6GL38
      Related
      ENSRNOP00000110454.1, ENSRNOT00000137379.1
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