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    Kif16b kinesin family member 16B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kif16bprovided by RGD
    Official Full Name
    kinesin family member 16Bprovided by RGD
    Primary source
    RGD:1310146
    See related
    EnsemblRapid:ENSRNOG00000004951 AllianceGenome:RGD:1310146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in several processes, including Golgi to endosome transport; cell surface receptor protein tyrosine kinase signaling pathway; and early endosome to late endosome transport. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in early endosome; phagocytic vesicle; and spindle. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Orthologous to human KIF16B (kinesin family member 16B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 118.4), Lung (RPKM 71.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif16b in Genome Data Viewer
    Location:
    3q41
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (150428233..150707755, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (129974692..130254194, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (136596621..136936809, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554505 Neighboring gene uncharacterized LOC120101717 Neighboring gene uncharacterized LOC120101718 Neighboring gene uncharacterized LOC134486454 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nuclear ribonucleoprotein polypeptide B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Hoepfner S, et al. Cell, 2005 May 6. PMID 15882625
    2. The structural basis of novel endosome anchoring activity of KIF16B kinesin. Blatner NR, et al. EMBO J, 2007 Aug 8. PMID 17641687, Free PMC Article
    3. KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor. Ueno H, et al. Dev Cell, 2011 Jan 18. PMID 21238925
    4. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formation of primary germ layer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF16B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107783.2 → NP_001101253.2  kinesin-like protein KIF16B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6K727
      Related
      ENSRNOP00000111013.1, ENSRNOT00000137987.1
      Conserved Domains (5) summary
      cd06874
      Location:1178 → 1305
      PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
      smart00129
      Location:3 → 365
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01365
      Location:2 → 365
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00498
      Location:478 → 543
      FHA; FHA domain
      pfam16183
      Location:364 → 476
      Kinesin_assoc; Kinesin-associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      150428233..150707755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283800.1 → XP_063139870.1  kinesin-like protein KIF16B isoform X10

      UniProtKB/TrEMBL
      A6K727, D3ZFN9
      Related
      ENSRNOP00000031372.5, ENSRNOT00000036273.6

    2. XM_039105043.2 → XP_038960971.1  kinesin-like protein KIF16B isoform X9

      UniProtKB/TrEMBL
      A6K727
      Conserved Domains (6) summary
      cd06874
      Location:1192 → 1319
      PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
      TIGR02168
      Location:833 → 1086
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01365
      Location:15 → 368
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam17380
      Location:614 → 889
      DUF5401; Family of unknown function (DUF5401)
      pfam00498
      Location:481 → 546
      FHA; FHA domain
      pfam16183
      Location:367 → 479
      Kinesin_assoc; Kinesin-associated

    3. XM_039105044.2 → XP_038960972.1  kinesin-like protein KIF16B isoform X11

      UniProtKB/TrEMBL
      A6K727
      Conserved Domains (6) summary
      cd06874
      Location:1181 → 1308
      PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
      COG1196
      Location:605 → 941
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:822 → 1075
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01365
      Location:15 → 368
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00498
      Location:481 → 546
      FHA; FHA domain
      pfam16183
      Location:367 → 479
      Kinesin_assoc; Kinesin-associated

    4. XM_006235113.5 → XP_006235175.2  kinesin-like protein KIF16B isoform X12

      UniProtKB/TrEMBL
      A6K727
      Related
      ENSRNOP00000082939.2, ENSRNOT00000118037.2
      Conserved Domains (6) summary
      TIGR02168
      Location:833 → 1086
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01365
      Location:15 → 368
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam17380
      Location:614 → 889
      DUF5401; Family of unknown function (DUF5401)
      pfam00498
      Location:481 → 546
      FHA; FHA domain
      pfam16183
      Location:367 → 479
      Kinesin_assoc; Kinesin-associated
      cl02563
      Location:1192 → 1274
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    5. XM_063283799.1 → XP_063139869.1  kinesin-like protein KIF16B isoform X8

    6. XM_039105041.2 → XP_038960969.1  kinesin-like protein KIF16B isoform X6

      Conserved Domains (5) summary
      TIGR00618
      Location:581 → 1149
      sbcc; exonuclease SbcC
      pfam17380
      Location:579 → 859
      DUF5401; Family of unknown function (DUF5401)
      pfam00498
      Location:451 → 516
      FHA; FHA domain
      pfam16183
      Location:337 → 449
      Kinesin_assoc; Kinesin-associated
      cl22853
      Location:1 → 338
      Motor_domain; Myosin and Kinesin motor domain

    7. XM_008762263.4 → XP_008760485.1  kinesin-like protein KIF16B isoform X5

      Conserved Domains (7) summary
      cd01365
      Location:5 → 353
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00225
      Location:1 → 346
      Kinesin; Kinesin motor domain
      pfam00498
      Location:466 → 531
      FHA; FHA domain
      pfam00769
      Location:750 → 870
      ERM; Ezrin/radixin/moesin family
      pfam12474
      Location:595 → 753
      PKK; Polo kinase kinase
      pfam16183
      Location:352 → 464
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:599 → 669
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    8. XM_063283798.1 → XP_063139868.1  kinesin-like protein KIF16B isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZVW2

    9. XM_006235108.5 → XP_006235170.1  kinesin-like protein KIF16B isoform X2

      Conserved Domains (7) summary
      smart00129
      Location:3 → 365
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01365
      Location:2 → 365
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00498
      Location:478 → 543
      FHA; FHA domain
      pfam00769
      Location:762 → 882
      ERM; Ezrin/radixin/moesin family
      pfam12474
      Location:607 → 765
      PKK; Polo kinase kinase
      pfam16183
      Location:364 → 476
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:611 → 681
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    10. XM_039105042.2 → XP_038960970.1  kinesin-like protein KIF16B isoform X7

      Conserved Domains (5) summary
      TIGR00618
      Location:572 → 1140
      sbcc; exonuclease SbcC
      pfam17380
      Location:570 → 850
      DUF5401; Family of unknown function (DUF5401)
      pfam00498
      Location:442 → 507
      FHA; FHA domain
      pfam16183
      Location:328 → 440
      Kinesin_assoc; Kinesin-associated
      cl22853
      Location:15 → 329
      Motor_domain; Myosin and Kinesin motor domain

    11. XM_039105039.2 → XP_038960967.1  kinesin-like protein KIF16B isoform X1

      Conserved Domains (5) summary
      TIGR00618
      Location:611 → 1179
      sbcc; exonuclease SbcC
      cd01365
      Location:15 → 368
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam17380
      Location:609 → 889
      DUF5401; Family of unknown function (DUF5401)
      pfam00498
      Location:481 → 546
      FHA; FHA domain
      pfam16183
      Location:367 → 479
      Kinesin_assoc; Kinesin-associated

    12. XM_039105040.2 → XP_038960968.1  kinesin-like protein KIF16B isoform X3

      Conserved Domains (5) summary
      COG1196
      Location:605 → 941
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:822 → 1075
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01365
      Location:15 → 368
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00498
      Location:481 → 546
      FHA; FHA domain
      pfam16183
      Location:367 → 479
      Kinesin_assoc; Kinesin-associated

    13. XM_008762265.4 → XP_008760487.1  kinesin-like protein KIF16B isoform X6

      See identical proteins and their annotated locations for XP_008760487.1

      Conserved Domains (5) summary
      TIGR00618
      Location:581 → 1149
      sbcc; exonuclease SbcC
      pfam17380
      Location:579 → 859
      DUF5401; Family of unknown function (DUF5401)
      pfam00498
      Location:451 → 516
      FHA; FHA domain
      pfam16183
      Location:337 → 449
      Kinesin_assoc; Kinesin-associated
      cl22853
      Location:1 → 338
      Motor_domain; Myosin and Kinesin motor domain

    RNA

    1. XR_005501888.2 RNA Sequence

      Related
      ENSRNOT00000162887.1
    Nucleotide Protein Strain
    Heading Accession and Version

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