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    Gsto1 glutathione S-transferase omega 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gsto1provided by RGD
    Official Full Name
    glutathione S-transferase omega 1provided by RGD
    Primary source
    RGD:70952
    See related
    EnsemblRapid:ENSRNOG00000071889 AllianceGenome:RGD:70952
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SPG-R
    Summary
    Enables glutathione dehydrogenase (ascorbate) activity. Involved in L-ascorbic acid biosynthetic process. Located in several cellular components, including basement membrane; cell body; and nuclear membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human GSTO1 (glutathione S-transferase omega 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 922.5), Adrenal (RPKM 568.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gsto1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (256662377..256672515)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (246721089..246731228)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267607437..267617387)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene glutathione S-transferase omega 2 Neighboring gene inositol 1,4,5-trisphosphate receptor interacting protein Neighboring gene uncharacterized LOC120100050 Neighboring gene microRNA 3584

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization of a glutathione-dependent dehydroascorbate reductase within specific rat brain regions. Fornai F, et al. Neuroscience, 2001. PMID 11311527
    2. Toward protein biomarkers for allergy: CD4+ T cell proteomics in allergic and nonallergic subjects sampled in and out of pollen season. Blüggel M, et al. J Proteome Res, 2011 Apr 1. PMID 21410266
    3. Purification and characterization of glutathione-dependent dehydroascorbate reductase from rat liver. Maellaro E, et al. Biochem J, 1994 Jul 15. PMID 8042991, Free PMC Article
    4. The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. Dulhunty A, et al. J Biol Chem, 2001 Feb 2. PMID 11035031
    5. Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. Zakharyan RA, et al. Chem Res Toxicol, 2001 Aug. PMID 11511179

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GSTO1 regulates insulin biosynthesis in pancreatic beta cells.
      Title: GSTO1 regulates insulin biosynthesis in pancreatic β cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC94845

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione dehydrogenase (ascorbate) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methylarsonate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-ascorbic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-ascorbic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-ascorbic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-ascorbic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to arsenic-containing substance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase omega-1
    Names
    GSTO 1-1
    GSTO-1
    MMA(V) reductase
    S-(Phenacyl)glutathione reductase
    glutathione S-transferase omega 1-1
    glutathione-dependent dehydroascorbate reductase
    monomethylarsonic acid reductase
    NP_001007603.1
    XP_038964778.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007602.1 → NP_001007603.1  glutathione S-transferase omega-1

      See identical proteins and their annotated locations for NP_001007603.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079363
      UniProtKB/Swiss-Prot
      Q9Z339
      UniProtKB/TrEMBL
      A6JHR8, B6DYQ5, F7F9Z0, Q6AXR6
      Related
      ENSRNOP00000107772.1, ENSRNOT00000128454.1
      Conserved Domains (3) summary
      cd03184
      Location:108 → 229
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      COG0625
      Location:26 → 214
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03055
      Location:5 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      256662377..256672515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108850.2 → XP_038964778.1  glutathione S-transferase omega-1 isoform X1

      Conserved Domains (2) summary
      cd03055
      Location:5 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:108 → 199
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z339.2 GenPept UniProtKB/Swiss-Prot:Q9Z339

    Gene LinkOut

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