Maml3 mastermind-like transcriptional coactivator 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maml3provided by RGD
Official Full Name: mastermind-like transcriptional coactivator 3provided by RGD
Primary source: RGD:1308177
See related: EnsemblRapid:ENSRNOG00000067338 AllianceGenome:RGD:1308177
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glrp1
Summary: Predicted to enable transcription coactivator activity. Predicted to be involved in Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Orthologous to human MAML3 (mastermind like transcriptional coactivator 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 64.2), Adrenal (RPKM 39.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (137871267..138288615, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (135720431..136137829, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (140734138..141276886, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139125 (e-PCR)
- UniSTS:221211

AW532352 (e-PCR)
- UniSTS:245577

AU025942 (e-PCR)
- UniSTS:114769

D2UIA9 (e-PCR)
- UniSTS:240476

AU048260 (e-PCR)
- UniSTS:109712

RH144645 (e-PCR)
- UniSTS:233890

RH135305 (e-PCR)
- UniSTS:218582

BI278034 (e-PCR)
- UniSTS:244195

D2Uwm9 (e-PCR)
- UniSTS:239848

BG375901 (e-PCR)
- UniSTS:243433

D2Got93 (e-PCR)
- UniSTS:114162

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription of Notch receptor target	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription of Notch receptor target	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mastermind-like protein 3

Names: glutamine repeat protein 1; mastermind like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107675.3 → NP_001101145.2 mastermind-like protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6ABZ3

Related

ENSRNOP00000089541.1, ENSRNOT00000097389.2

Conserved Domains (1) summary

pfam09596
Location:67 → 124

MamL-1; MamL-1 domain