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    Trmt2a tRNA methyltransferase 2 homolog A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287953, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trmt2aprovided by RGD
    Official Full Name
    tRNA methyltransferase 2 homolog Aprovided by RGD
    Primary source
    RGD:1310418
    See related
    EnsemblRapid:ENSRNOG00000001885 AllianceGenome:RGD:1310418
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Htf9c
    Summary
    Predicted to enable C-methyltransferase activity and tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent. Predicted to be involved in RNA processing and methylation. Orthologous to human TRMT2A (tRNA methyltransferase 2 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 119.3), Spleen (RPKM 95.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Trmt2a in Genome Data Viewer
    Location:
    11q23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96241998..96246719, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82737689..82742423, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86885671..86890482, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene microRNA 1306 Neighboring gene sialic acid synthase-like Neighboring gene RAN binding protein 1 Neighboring gene small nucleolar RNA, H/ACA box 77B Neighboring gene zinc finger DHHC-type palmitoyltransferase 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in RNA processing  
    involved_in methylation  

    General protein information

    Preferred Names
    tRNA (uracil-5-)-methyltransferase homolog A
    Names
    HpaII tiny fragments locus 9c
    TRM2 tRNA methyltransferase 2 homolog A
    NP_001011895.1
    XP_006248667.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011895.1NP_001011895.1  tRNA (uracil-5-)-methyltransferase homolog A

      See identical proteins and their annotated locations for NP_001011895.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083619
      UniProtKB/TrEMBL
      A0A8I5ZNM4, A6JSH8, F7F7M9, Q5XIQ6
      Related
      ENSRNOP00000044510.3, ENSRNOT00000046183.6
      Conserved Domains (4) summary
      COG0724
      Location:61202
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      COG2265
      Location:170572
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cd12439
      Location:59137
      RRM_TRMT2A; RNA recognition motif in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins
      cl17173
      Location:376579
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96241998..96246719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248605.4XP_006248667.1  tRNA (uracil-5-)-methyltransferase homolog A isoform X1

      See identical proteins and their annotated locations for XP_006248667.1

      UniProtKB/TrEMBL
      A0A8I5ZNM4
      Related
      ENSRNOP00000079605.1, ENSRNOT00000105074.2
      Conserved Domains (2) summary
      cd12439
      Location:47125
      RRM_TRMT2A; RNA recognition motif (RRM) found in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins
      cl17173
      Location:158560
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_010055938.1 RNA Sequence

    2. XR_005490992.2 RNA Sequence

    3. XR_005490993.2 RNA Sequence

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