Ss18l1 SS18L1 subunit of BAF chromatin remodeling complex [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ss18l1provided by RGD
Official Full Name: SS18L1 subunit of BAF chromatin remodeling complexprovided by RGD
Primary source: RGD:621847
See related: EnsemblRapid:ENSRNOG00000060010 AllianceGenome:RGD:621847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CREST
Summary: Predicted to enable transcription coactivator activity. Involved in positive regulation of DNA-templated transcription and regulation of dendrite development. Located in nuclear body. Orthologous to human SS18L1 (SS18L1 subunit of BAF chromatin remodeling complex). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 116.0), Brain (RPKM 115.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (187521616..187542873)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (167143730..167165253)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (175426754..175445222)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein expression pattern of calcium-responsive transactivator in early postnatal and adult testes.
Title: Protein expression pattern of calcium-responsive transactivator in early postnatal and adult testes.
CREST in the nucleus accumbens core is required for cocaine-induced conditioned place preference, synaptic plasticity and cocaine-seeking behavior.
Title: CREST in the Nucleus Accumbens Core Regulates Cocaine Conditioned Place Preference, Cocaine-Seeking Behavior, and Synaptic Plasticity.
The results indicated that CREST is implicated in beta-cell apoptosis induced by culture in high glucose.
Title: Involvement of the Ca2+-responsive transactivator in high glucose-induced β-cell apoptosis.
analysis of the CREST domain that inhibits dendritic growth in cultured neurons
Title: A multifunctional domain of the calcium-responsive transactivator (CREST) that inhibits dendritic growth in cultured neurons.
calcium activation of CREST-mediated transcription helps regulate neuronal morphogenesis
Title: Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendrite development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
part_of nBAF complex	IEA Inferred from Electronic Annotation more info
part_of nBAF complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium-responsive transcription coactivator

Names: SS18-like protein 1; SS18L1, nBAF chromatin remodeling complex subunit; calcium-responsive transactivator; synovial sarcoma translocation gene on chromosome 18-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138918.2 → NP_620273.2 calcium-responsive transcription coactivator

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q91XJ0

UniProtKB/TrEMBL

A0A8I5ZQS4, A6KMC5

Related

ENSRNOP00000080662.1, ENSRNOT00000111398.2

Conserved Domains (1) summary

pfam05030
Location:14 → 73

SSXT; SSXT protein (N-terminal region)