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    Pemt phosphatidylethanolamine N-methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25511, updated on 27-Dec-2024

    Summary

    Official Symbol
    Pemtprovided by RGD
    Official Full Name
    phosphatidylethanolamine N-methyltransferaseprovided by RGD
    Primary source
    RGD:3297
    See related
    EnsemblRapid:ENSRNOG00000054423 AllianceGenome:RGD:3297
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PLMT; Pempt; PHOMETH
    Summary
    Enables phosphatidylethanolamine N-methyltransferase activity and phosphatidylethanolamine binding activity. Involved in several processes, including S-adenosylhomocysteine metabolic process; positive regulation of lipoprotein metabolic process; and response to ethanol. Located in brush border membrane and sarcolemma. Biomarker of metabolic dysfunction and alcohol associated liver disease. Orthologous to human PEMT (phosphatidylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1309.8) and Testes (RPKM 43.3) See more
    Orthologs
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    Genomic context

    See Pemt in Genome Data Viewer
    Location:
    10q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45275434..45349651, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (44775910..44849990, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46339821..46404640, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 9 Neighboring gene ras related dexamethasone induced 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene 3 Neighboring gene uncharacterized LOC102549418 Neighboring gene retinoic acid induced 1 Neighboring gene sterol regulatory element binding transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine metabolic process PubMed 
    involved_in S-adenosylmethionine metabolic process PubMed 
    acts_upstream_of_or_within blastocyst hatching  
    involved_in glycerophospholipid metabolic process PubMed 
    involved_in methylation  
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in phosphatidylcholine biosynthetic process  
    involved_in phosphatidylcholine biosynthetic process PubMed 
    involved_in phosphatidylcholine biosynthetic process  
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of lipoprotein metabolic process PubMed 
    involved_in response to amino acid PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to vitamin PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within sphingomyelin biosynthetic process  
    Component Evidence Code Pubs
    located_in brush border membrane PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in intracellular membrane-bounded organelle  
    located_in mitochondrial membrane  
    located_in mitochondrion  
    located_in sarcolemma PubMed 

    General protein information

    Preferred Names
    phosphatidylethanolamine N-methyltransferase
    Names
    PE N-methyltransferase
    PEAMT
    phospholipid methyltransferase
    NP_037135.1
    XP_038941214.1
    XP_063124541.1
    XP_063124542.1
    XP_063124543.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013003.2NP_037135.1  phosphatidylethanolamine N-methyltransferase

      See identical proteins and their annotated locations for NP_037135.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q08388, Q5BK89
      UniProtKB/TrEMBL
      A6HF23
      Related
      ENSRNOP00000100443.1, ENSRNOT00000163705.1
      Conserved Domains (1) summary
      pfam04191
      Location:102191
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      45275434..45349651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085286.2XP_038941214.1  phosphatidylethanolamine N-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJS4, A0A8L2RBC3
      Related
      ENSRNOP00000074801.2, ENSRNOT00000083698.3
      Conserved Domains (1) summary
      pfam04191
      Location:138227
      PEMT; Phospholipid methyltransferase
    2. XM_063268471.1XP_063124541.1  phosphatidylethanolamine N-methyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8I6GAY9
      Related
      ENSRNOP00000084752.1, ENSRNOT00000112526.2
    3. XM_063268472.1XP_063124542.1  phosphatidylethanolamine N-methyltransferase isoform X3

    4. XM_063268473.1XP_063124543.1  phosphatidylethanolamine N-methyltransferase isoform X4

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