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    Gpr146 G protein-coupled receptor 146 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr146provided by RGD
    Official Full Name
    G protein-coupled receptor 146provided by RGD
    Primary source
    RGD:1560731
    See related
    EnsemblRapid:ENSRNOG00000001288 AllianceGenome:RGD:1560731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560731
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of cholesterol biosynthetic process. Predicted to be active in plasma membrane. Orthologous to human GPR146 (G protein-coupled receptor 146). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 311.1), Lung (RPKM 121.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr146 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20365790..20381122, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15251936..15267217, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17343396..17358631, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 7 open reading frame 50 Neighboring gene RIKEN cDNA C130050O18 gene like Neighboring gene G protein-coupled estrogen receptor 1 Neighboring gene microRNA 339 Neighboring gene cytochrome P450, family 2, subfamily w, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells. Jiang Y, et al. Eur J Pharmacol, 2023 Feb 15. PMID 36638952
    2. Evidence for an interaction between proinsulin C-peptide and GPR146. Yosten GL, et al. J Endocrinol, 2013. PMID 23759446
    3. Investigation into the presence and functional significance of proinsulin C-peptide in the female germline†. Martin JH, et al. Biol Reprod, 2019 May 1. PMID 30715203

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells.
      Title: Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 146

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109062.1 → NP_001102532.1  probable G-protein coupled receptor 146

      See identical proteins and their annotated locations for NP_001102532.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474012
      UniProtKB/TrEMBL
      A6K1V9, D3ZIS6
      Conserved Domains (1) summary
      cd14990
      Location:27 → 305
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      20365790..20381122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248957.5 → XP_006249019.1  probable G-protein coupled receptor 146 isoform X1

      See identical proteins and their annotated locations for XP_006249019.1

      UniProtKB/TrEMBL
      A6K1V9, D3ZIS6
      Conserved Domains (1) summary
      cd14990
      Location:27 → 305
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_017598438.3 → XP_017453927.1  probable G-protein coupled receptor 146 isoform X1

      UniProtKB/TrEMBL
      A6K1V9, D3ZIS6
      Related
      ENSRNOP00000092167.1, ENSRNOT00000095799.2
      Conserved Domains (1) summary
      cd14990
      Location:27 → 305
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_039089691.2 → XP_038945619.1  probable G-protein coupled receptor 146 isoform X1

      UniProtKB/TrEMBL
      A6K1V9, D3ZIS6
      Conserved Domains (1) summary
      cd14990
      Location:27 → 305
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_039089692.2 → XP_038945620.1  probable G-protein coupled receptor 146 isoform X1

      UniProtKB/TrEMBL
      A6K1V9, D3ZIS6
      Related
      ENSRNOP00000097739.1, ENSRNOT00000106521.2
      Conserved Domains (1) summary
      cd14990
      Location:27 → 305
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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