Rhpn2 rhophilin, Rho GTPase binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rhpn2provided by RGD
Official Full Name: rhophilin, Rho GTPase binding protein 2provided by RGD
Primary source: RGD:1308366
See related: EnsemblRapid:ENSRNOG00000011885 AllianceGenome:RGD:1308366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in negative regulation of stress fiber assembly. Predicted to act upstream of or within glomerular filtration. Predicted to be located in plasma membrane. Orthologous to several human genes including RHPN2 (rhophilin Rho GTPase binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 57.2), Liver (RPKM 43.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (97128054..97188803)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (87991143..88051895)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (91596344..91657395)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143215 (e-PCR)
- UniSTS:232462

RH124304 (e-PCR)
- UniSTS:161126

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rhophilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107505.2 → NP_001100975.1 rhophilin-2

See identical proteins and their annotated locations for NP_001100975.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6JAA8, D4A8N7

Related

ENSRNOP00000016148.5, ENSRNOT00000016148.7

Conserved Domains (3) summary

cd11634
Location:27 → 108

HR1_Rhophilin-2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-2

cd00992
Location:520 → 591

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl14649
Location:112 → 496

BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains