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    Prcc proline rich mitotic checkpoint control factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310687, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prccprovided by RGD
    Official Full Name
    proline rich mitotic checkpoint control factorprovided by RGD
    Primary source
    RGD:1309037
    See related
    EnsemblRapid:ENSRNOG00000012933 AllianceGenome:RGD:1309037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of cell cycle. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in papillary renal cell carcinoma. Orthologous to human PRCC (proline rich mitotic checkpoint control factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 131.5), Heart (RPKM 127.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prcc in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175624134..175649664, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173326261..173351799, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187232458..187258140, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene insulin receptor-related receptor Neighboring gene SH2 domain containing 2A Neighboring gene heparin binding growth factor Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene methyltransferase like 25B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proline-rich protein PRCC
    Names
    papillary renal cell carcinoma (translocation-associated)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107700.2NP_001101170.1  proline-rich protein PRCC

      See identical proteins and their annotated locations for NP_001101170.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AEX5, A0A9K3Y8G4, B2RYA6, F1M986
      Related
      ENSRNOP00000017735.6, ENSRNOT00000017735.9
      Conserved Domains (1) summary
      pfam10253
      Location:368489
      PRCC; Mitotic checkpoint regulator, MAD2B-interacting

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      175624134..175649664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)