Arrb1 arrestin, beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arrb1provided by RGD
Official Full Name: arrestin, beta 1provided by RGD
Primary source: RGD:2156
See related: EnsemblRapid:ENSRNOG00000030404 AllianceGenome:RGD:2156
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BARRES
Summary: Enables several functions, including AP-2 adaptor complex binding activity; G protein-coupled receptor binding activity; and arrestin family protein binding activity. Involved in several processes, including regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and regulation of protein metabolic process. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density. Used to study congestive heart failure. Biomarker of colitis. Orthologous to human ARRB1 (arrestin beta 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 340.3), Brain (RPKM 227.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (163249654..163321711)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (153837964..153912111)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (164502099..164573947)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARRB1 inhibits extracellular matrix degradation and apoptosis of nucleus pulposus cells by promoting autophagy and attenuates intervertebral disc degeneration.
Title: ARRB1 inhibits extracellular matrix degradation and apoptosis of nucleus pulposus cells by promoting autophagy and attenuates intervertebral disc degeneration.
miR-22-3p in the rostral ventrolateral medulla promotes hypertension through inhibiting beta-arrestin-1.
Title: miR-22-3p in the rostral ventrolateral medulla promotes hypertension through inhibiting β-arrestin-1.
Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins.
Title: Conformational Dynamics and Functional Implications of Phosphorylated β-Arrestins.
Knockdown of beta-arrestin1 or 2 in the post-MI cardiac fibroblasts (CF) inhibited transformation to myofibroblasts as well as basal and TGF-beta-stimulated collagen synthesis. These data suggest that beta-arrestins can regulate CF biology.
Title: Regulation of cardiac fibroblast-mediated maladaptive ventricular remodeling by β-arrestins.
Our results indicate reduced involvement of betaarr1 in dampening Angiotensin II-induced mitogen-activated protein kinase activation and diminished betaarr1-mediated ERK and p38 activation in spontaneously hypertensive rat brainstem astrocytes
Title: Role of βarrestin1 in AT(1) R-mediated mitogen-activated protein kinase activation in Wistar and SHR brainstem astrocytes.
Tyrosine hydroxylase upregulate beta-arrestin-1 in astrocytes to facilitate endocytosis of beta2-AR, required for endosomal ERK activation to drive the differentiation process.
Title: Thyroid Hormone-Induced Differentiation of Astrocytes is Associated with Transcriptional Upregulation of β-arrestin-1 and β-adrenergic Receptor-Mediated Endosomal Signaling.
Berberine exhibited renoprotective effects in diabetic nephropathy (DN), and the underlying molecular mechanisms may be associated with changes in the levels and regulation of beta-arrestin 1/2 expression, as well as intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) levels in the kidney.
Title: Renoprotective effects of berberine and its potential effect on the expression of β-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in streptozocin-diabetic nephropathy rats.
Results suggested that beta-arr1 and 2 may differently modulate mGluR7 signaling in developmental sevoflurane neurotoxicity
Title: Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis.
Microinfusions of Arrb1 antisense oligodeoxynucleotides into female rat hypothalamus knocked down Arrb1 and prevented estradiol benzoate-induced lordosis behavior.
Title: β-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons.
The studies reveal how CB1 receptor activation translates into beta-arrestin 1/ beta-arrestin 2 signaling and identify a mechanism to control this pathway.
Title: Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AP-2 adaptor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables V2 vasopressin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables alpha-1A adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha-1B adrenergic receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables angiotensin receptor binding	ISO Inferred from Sequence Orthology more info
enables arrestin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables arrestin family protein binding	ISO Inferred from Sequence Orthology more info
enables clathrin adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables clathrin binding	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables follicle-stimulating hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphorylated amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in follicle-stimulating hormone signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phototransduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of inositol trisphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to morphine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of touch	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in pseudopodium	IEA Inferred from Electronic Annotation more info
located_in pseudopodium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-arrestin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012910.2 → NP_037042.1 beta-arrestin-1

See identical proteins and their annotated locations for NP_037042.1

Status: PROVISIONAL

Source sequence(s)

M91589

UniProtKB/Swiss-Prot

P29066

UniProtKB/TrEMBL

A0A8I6GL31

Related

ENSRNOP00000095275.2, ENSRNOT00000118341.2

Conserved Domains (2) summary

smart01017
Location:193 → 356

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:18 → 174

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

163249654..163321711

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229740.5 → XP_006229802.1 beta-arrestin-1 isoform X10

UniProtKB/TrEMBL

A0A8I6GL31

Conserved Domains (2) summary

smart01017
Location:203 → 366

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:18 → 184

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_063281770.1 → XP_063137840.1 beta-arrestin-1 isoform X13

UniProtKB/TrEMBL

A0A8I6GL31
XM_063281776.1 → XP_063137846.1 beta-arrestin-1 isoform X16

UniProtKB/TrEMBL

A0A8I6GL31
XM_063281772.1 → XP_063137842.1 beta-arrestin-1 isoform X14

UniProtKB/TrEMBL

A0A8I6GL31
XM_006229738.5 → XP_006229800.1 beta-arrestin-1 isoform X5

UniProtKB/TrEMBL

A0A8I6GL31

Conserved Domains (2) summary

smart01017
Location:256 → 419

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:71 → 237

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_039101664.2 → XP_038957592.1 beta-arrestin-1 isoform X6

UniProtKB/TrEMBL

A0A8I6GL31

Conserved Domains (2) summary

smart01017
Location:256 → 411

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:71 → 237

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_039101685.2 → XP_038957613.1 beta-arrestin-1 isoform X17

Conserved Domains (1) summary

pfam00339
Location:71 → 224

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_006229735.5 → XP_006229797.1 beta-arrestin-1 isoform X2

UniProtKB/TrEMBL

A0A8I6GL31

Conserved Domains (2) summary

smart01017
Location:256 → 411

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:71 → 237

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_039101614.2 → XP_038957542.1 beta-arrestin-1 isoform X1

UniProtKB/TrEMBL

A0A8I6GL31

Conserved Domains (2) summary

smart01017
Location:256 → 419

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:71 → 237

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_063281752.1 → XP_063137822.1 beta-arrestin-1 isoform X7

UniProtKB/TrEMBL

A0A8I6GL31
XM_006229737.5 → XP_006229799.1 beta-arrestin-1 isoform X4

UniProtKB/TrEMBL

A0A8I6G7K6, A0A8I6GL31

Related

ENSRNOP00000102308.1, ENSRNOT00000153802.1

Conserved Domains (2) summary

smart01017
Location:246 → 401

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:71 → 227

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_006229736.5 → XP_006229798.1 beta-arrestin-1 isoform X3

UniProtKB/TrEMBL

A0A8I6GL31

Conserved Domains (2) summary

smart01017
Location:246 → 409

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:71 → 227

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_006229741.5 → XP_006229803.1 beta-arrestin-1 isoform X11

UniProtKB/TrEMBL

A0A8I6GL31

Conserved Domains (2) summary

smart01017
Location:198 → 361

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:13 → 179

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_063281775.1 → XP_063137845.1 beta-arrestin-1 isoform X15

UniProtKB/TrEMBL

A0A8I6GL31

Related

ENSRNOP00000112649.1, ENSRNOT00000143451.1
XM_006229739.5 → XP_006229801.1 beta-arrestin-1 isoform X8

UniProtKB/TrEMBL

A0A8I6GL31

Conserved Domains (2) summary

smart01017
Location:215 → 378

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:30 → 196

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_063281756.1 → XP_063137826.1 beta-arrestin-1 isoform X9

UniProtKB/TrEMBL

A0A8I6GL31, A0A8L2QMJ8

Related

ENSRNOP00000046069.4, ENSRNOT00000043554.6
XM_063281766.1 → XP_063137836.1 beta-arrestin-1 isoform X12

UniProtKB/TrEMBL

A0A8I6GL31

Related

ENSRNOP00000110444.1, ENSRNOT00000125345.1