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    Cdkn2aip CDKN2A interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdkn2aipprovided by RGD
    Official Full Name
    CDKN2A interacting proteinprovided by RGD
    Primary source
    RGD:1305302
    See related
    EnsemblRapid:ENSRNOG00000022736 AllianceGenome:RGD:1305302
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305302
    Summary
    Predicted to enable p53 binding activity. Predicted to be involved in several processes, including DNA damage response; regulation of cell growth; and regulation of protein stability. Predicted to be located in granular component. Predicted to be active in nucleolus and nucleoplasm. Orthologous to human CDKN2AIP (CDKN2A interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 159.1), Thymus (RPKM 114.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdkn2aip in Genome Data Viewer
    Location:
    16q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (51266613..51274051)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44536147..44546216)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47664864..47670935)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482379 Neighboring gene proteasome subunit alpha type-5-like Neighboring gene uncharacterized LOC102551260 Neighboring gene uncharacterized LOC134482502 Neighboring gene inhibitor of growth family, member 2 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control. Hasan MK, et al. Biochem J, 2004 Jun 15. PMID 15109303, Free PMC Article
    2. Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. Cheung CT, et al. J Biol Chem, 2014 Jun 27. PMID 24825908, Free PMC Article
    3. A novel putative collaborator of p19ARF. Wadhwa R, et al. Exp Gerontol, 2003 Mar. PMID 12581788
    4. CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. Hasan MK, et al. J Biol Chem, 2002 Oct 4. PMID 12154087
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112660

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in granular component ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CDKN2A-interacting protein
    Names
    collaborator of ARF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014000.1 → NP_001014022.1  CDKN2A-interacting protein

      See identical proteins and their annotated locations for NP_001014022.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085832
      UniProtKB/Swiss-Prot
      Q4KM89, Q5U2X0
      UniProtKB/TrEMBL
      A0A8I6AJX9, A6JPK7
      Related
      ENSRNOP00000029705.4, ENSRNOT00000030519.6
      Conserved Domains (1) summary
      pfam11952
      Location:19 → 117
      XTBD; XRN-Two Binding Domain, XTBD

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      51266613..51274051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094518.2 → XP_038950446.1  CDKN2A-interacting protein isoform X1

      Conserved Domains (1) summary
      pfam11952
      Location:19 → 117
      XTBD; XRN-Two Binding Domain, XTBD

    2. XM_006253147.5 → XP_006253209.1  CDKN2A-interacting protein isoform X2

      See identical proteins and their annotated locations for XP_006253209.1

      UniProtKB/Swiss-Prot
      Q5U2X0
      Conserved Domains (1) summary
      pfam11952
      Location:19 → 117
      XTBD; XRN-Two Binding Domain, XTBD
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2X0.1 GenPept UniProtKB/Swiss-Prot:Q5U2X0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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