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    Kcnh8 potassium voltage-gated channel subfamily H member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnh8provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily H member 8provided by RGD
    Primary source
    RGD:2549
    See related
    EnsemblRapid:ENSRNOG00000058626 AllianceGenome:RGD:2549
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ELK3; Elk1; Ets-1; RELK3
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and delayed rectifier potassium channel activity. Involved in negative regulation of apoptotic process; potassium ion transport; and response to aldosterone. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of retinal degeneration. Orthologous to human KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 7.2), Testes (RPKM 1.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnh8 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (5742683..6182445)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (5506044..5945828)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (3127618..3697736, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Fcf1 rRNA-processing protein, pseudogene 6 Neighboring gene uncharacterized LOC134480318 Neighboring gene uncharacterized LOC134480321 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134480320 Neighboring gene ribosomal protein S17, pseudogene 11 Neighboring gene ribosomal protein S26, pseudogene 12 Neighboring gene cofilin 1, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain. Martin S, et al. Neuroscience, 2008 Aug 26. PMID 18650019
    2. Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter. Zhang C, et al. J Biol Chem, 2003 Jul 25. PMID 12740370
    3. Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. Saganich MJ, et al. J Neurosci, 2001 Jul 1. PMID 11425889, Free PMC Article
    4. Cloning and functional expression of rat ether-à-go-go-like K+ channel genes. Engeland B, et al. J Physiol, 1998 Dec 15. PMID 9824707, Free PMC Article
    5. Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia. Shi W, et al. J Physiol, 1998 Sep 15. PMID 9714851, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that Eag1 protein expression greatly overlaps with mRNA distribution in rat.
      Title: Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables delayed rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to aldosterone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated delayed rectifier potassium channel KCNH8
    Names
    ELK channel 3
    ether-a-go-go-like potassium channel 1
    ether-a-go-go-like potassium channel 3
    potassium channel, voltage gated eag related subfamily H, member 8
    potassium voltage-gated channel, subfamily H (eag-related), member 8
    voltage-gated potassium channel subunit Kv12.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145095.2 → NP_659563.1  voltage-gated delayed rectifier potassium channel KCNH8

      See identical proteins and their annotated locations for NP_659563.1

      Status: PROVISIONAL

      Source sequence(s)
      AF061957
      UniProtKB/Swiss-Prot
      O88877, Q9QWS8
      UniProtKB/TrEMBL
      A6KPQ1
      Related
      ENSRNOP00000074122.3, ENSRNOT00000087331.3
      Conserved Domains (6) summary
      COG0664
      Location:548 → 707
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:551 → 662
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:42 → 133
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:239 → 481
      Ion_trans; Ion transport protein
      pfam07885
      Location:421 → 475
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 135
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      5742683..6182445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWS8.2 GenPept UniProtKB/Swiss-Prot:Q9QWS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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