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    Eogt EGF domain specific O-linked N-acetylglucosamine transferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eogtprovided by RGD
    Official Full Name
    EGF domain specific O-linked N-acetylglucosamine transferaseprovided by RGD
    Primary source
    RGD:1359357
    See related
    EnsemblRapid:ENSRNOG00000024533 AllianceGenome:RGD:1359357
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aer61
    Summary
    Predicted to enable protein O-acetylglucosaminyltransferase activity. Predicted to be involved in protein O-GlcNAcylation via threonine. Predicted to be active in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 116.3), Lung (RPKM 109.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eogt in Genome Data Viewer
    Location:
    4q34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (131275587..131313243, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (129718897..129756558, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (129477779..129515435, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 4 Neighboring gene uncharacterized LOC134486820 Neighboring gene uncharacterized LOC134486821 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene TATA element modulatory factor 1 Neighboring gene ubiquitin-like modifier activating enzyme 3 Neighboring gene ARF like GTPase 6 interacting protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Sakaidani Y, et al. Biochem Biophys Res Commun, 2012 Mar 2. PMID 22310717
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-GlcNAcylation via threonine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EGF domain-specific O-linked N-acetylglucosamine transferase
    Names
    EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
    extracellular O-linked N-acetylglucosamine transferase
    glycosyltransferase Aer61
    NP_001009502.1
    XP_008761367.1
    XP_017448253.1
    XP_017448254.1
    XP_017448255.1
    XP_038963971.1
    XP_038963972.1
    XP_063142516.1
    XP_063142517.1
    XP_063142519.1
    XP_063142520.1
    XP_063142521.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009502.2 → NP_001009502.1  EGF domain-specific O-linked N-acetylglucosamine transferase precursor

      See identical proteins and their annotated locations for NP_001009502.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q5NDL0
      UniProtKB/TrEMBL
      A6IBF3
      Conserved Domains (1) summary
      pfam04577
      Location:245 → 468
      DUF563; Protein of unknown function (DUF563)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      131275587..131313243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592766.3 → XP_017448255.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X4

      Related
      ENSRNOP00000105223.1, ENSRNOT00000130855.1
      Conserved Domains (1) summary
      pfam04577
      Location:253 → 476
      DUF563; Protein of unknown function (DUF563)

    2. XM_039108043.2 → XP_038963971.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X3

      Conserved Domains (1) summary
      pfam04577
      Location:283 → 477
      DUF563; Protein of unknown function (DUF563)

    3. XM_063286449.1 → XP_063142519.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X5

      UniProtKB/Swiss-Prot
      Q5NDL0
      UniProtKB/TrEMBL
      A6IBF3

    4. XM_008763145.4 → XP_008761367.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4R9
      Related
      ENSRNOP00000073147.2, ENSRNOT00000077530.3
      Conserved Domains (1) summary
      pfam04577
      Location:282 → 505
      DUF563; Protein of unknown function (DUF563)

    5. XM_017592764.3 → XP_017448253.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4R9
      Related
      ENSRNOP00000105600.1, ENSRNOT00000154943.1
      Conserved Domains (1) summary
      pfam04577
      Location:283 → 506
      DUF563; Protein of unknown function (DUF563)

    6. XM_063286446.1 → XP_063142516.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

    7. XM_063286447.1 → XP_063142517.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X4

    8. XM_017592765.3 → XP_017448254.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4R9
      Conserved Domains (1) summary
      pfam04577
      Location:283 → 506
      DUF563; Protein of unknown function (DUF563)

    9. XM_063286450.1 → XP_063142520.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X5

      UniProtKB/Swiss-Prot
      Q5NDL0
      UniProtKB/TrEMBL
      A6IBF3

    10. XM_039108044.2 → XP_038963972.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X7

      Conserved Domains (1) summary
      pfam04577
      Location:8 → 231
      DUF563; Protein of unknown function (DUF563)

    11. XM_063286451.1 → XP_063142521.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NDL0.1 GenPept UniProtKB/Swiss-Prot:Q5NDL0

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