Banf1 barrier to autointegration nuclear assembly factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Banf1provided by RGD
Official Full Name: barrier to autointegration nuclear assembly factor 1provided by RGD
Primary source: RGD:620662
See related: EnsemblRapid:ENSRNOG00000020460 AllianceGenome:RGD:620662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Baf; Bcrp1; L2bp1; L2bp1/Baf
Summary: Enables identical protein binding activity. Predicted to be involved in several processes, including negative regulation of type I interferon production; negative regulation of viral genome replication; and regulation of innate immune response. Predicted to act upstream of or within DNA integration. Located in condensed chromosome. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Nestor-Guillermo progeria syndrome. Orthologous to human BANF1 (barrier to autointegration nuclear assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 474.6), Heart (RPKM 389.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (212101523..212103568, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (202672170..202674215, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (220744195..220746224, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
Title: LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134653 (e-PCR)
- UniSTS:217932

RH126339 (e-PCR)
- UniSTS:163047

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA integration	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic nuclear membrane reassembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic nuclear membrane reassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
is_active_in condensed chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: barrier-to-autointegration factor

Names: BAF nuclear assembly factor 1; Breakpoint cluster region protein, uterine leiomyoma, 1; Breakpoint cluster region protein, uterine leiomyoma, 1; barrier to autointegration factor; LAP2-binding protein 1; Lap2 binding protein 1; barrier to autointegration factor 1; breakpoint cluster region protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053631.3 → NP_446083.1 barrier-to-autointegration factor

See identical proteins and their annotated locations for NP_446083.1

Status: VALIDATED

Source sequence(s)

BC084726, CB766065, JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9R1T1

Related

ENSRNOP00000027734.3, ENSRNOT00000027734.7

Conserved Domains (1) summary

pfam02961
Location:1 → 86

BAF; Barrier to autointegration factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

212101523..212103568 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230631.3 → XP_006230693.1 barrier-to-autointegration factor isoform X1

See identical proteins and their annotated locations for XP_006230693.1

UniProtKB/Swiss-Prot

Q9R1T1

Conserved Domains (1) summary

pfam02961
Location:1 → 86

BAF; Barrier to autointegration factor
XM_039106718.2 → XP_038962646.1 barrier-to-autointegration factor isoform X1

UniProtKB/Swiss-Prot

Q9R1T1

Conserved Domains (1) summary

pfam02961
Location:1 → 86

BAF; Barrier to autointegration factor
XM_006230630.5 → XP_006230692.1 barrier-to-autointegration factor isoform X1

See identical proteins and their annotated locations for XP_006230692.1

UniProtKB/Swiss-Prot

Q9R1T1

Conserved Domains (1) summary

pfam02961
Location:1 → 86

BAF; Barrier to autointegration factor