Gipc1 GIPC PDZ domain containing family, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gipc1provided by RGD
Official Full Name: GIPC PDZ domain containing family, member 1provided by RGD
Primary source: RGD:68338
See related: EnsemblRapid:ENSRNOG00000003864 AllianceGenome:RGD:68338
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gipc; Rgs19; Rgs19ip1
Summary: Enables PDZ domain binding activity. Predicted to be involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of melanin biosynthetic process; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including cellular response to interleukin-7; endothelial cell migration; and glutamate secretion. Located in brush border and endocytic vesicle. Is active in Schaffer collateral - CA1 synapse; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 2. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 90.1), Adrenal (RPKM 73.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (41380125..41392078, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (24474291..24487083, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (24786604..24798231)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha.
Title: Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.
GIPC may be preferentially associated with extrasynaptic N-methyl-D-aspartate (NMDA) receptors and may play a role in the organization and trafficking of this receptor population.
Title: The role of the PDZ protein GIPC in regulating NMDA receptor trafficking.
Results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity.
Title: BDNF-mediated neurotransmission relies upon a myosin VI motor complex.
RGS-GAIP functions as a bifunctional adaptor that binds to G alpha subunits through its RGS domain and to GIPN through its cysteine string motif.
Title: Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP.
GIPC acts as a selective scaffold protein to assist receptor functions.
Title: Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors.
Synectin plays a role in neural development and regeneration in association with TrkB receptor [synectin]
Title: Synectin in the nervous system: expression pattern and potential as a binding partner of neurotrophin receptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables myosin binding	IEA Inferred from Electronic Annotation more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to interleukin-7	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-7	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in glutamate secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein targeting	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PDZ domain-containing protein GIPC1

Names: GAIP C-terminus-interacting protein; GLUT1 C-terminal-binding protein; GLUT1CBP; RGS-GAIP interacting protein, C-terminus; RGS-GAIP-interacting protein; RGS19-interacting protein 1; regulator of G-protein signaling 19 interacting protein 1; synectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053341.3 → NP_445793.1 PDZ domain-containing protein GIPC1

See identical proteins and their annotated locations for NP_445793.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q6GR70, Q9QUQ4, Q9Z254

UniProtKB/TrEMBL

A6IYD6

Related

ENSRNOP00000089319.2, ENSRNOT00000105318.2

Conserved Domains (2) summary

cd00992
Location:132 → 211

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd21180
Location:261 → 325

GH2_GIPC; GIPC-homology 2 (GH2) domain found in the GIPC family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

41380125..41392078 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098035.2 → XP_038953963.1 PDZ domain-containing protein GIPC1 isoform X1

UniProtKB/Swiss-Prot

Q6GR70, Q9QUQ4, Q9Z254

UniProtKB/TrEMBL

A6IYD6

Related

ENSRNOP00000005374.3, ENSRNOT00000005374.7

Conserved Domains (2) summary

cd00992
Location:132 → 211

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd21180
Location:261 → 325

GH2_GIPC; GIPC-homology 2 (GH2) domain found in the GIPC family
XM_017601372.3 → XP_017456861.1 PDZ domain-containing protein GIPC1 isoform X1

UniProtKB/Swiss-Prot

Q6GR70, Q9QUQ4, Q9Z254

UniProtKB/TrEMBL

A6IYD6

Conserved Domains (2) summary

cd00992
Location:132 → 211

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd21180
Location:261 → 325

GH2_GIPC; GIPC-homology 2 (GH2) domain found in the GIPC family