Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cyp11b1provided by RGD
Full Name: cytochrome P450, family 11, subfamily b, polypeptide 1provided by RGD
Primary source: RGD:2453
See related: EnsemblRapid:ENSRNOG00000071398 AllianceGenome:RGD:2453
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cp11ba; CYPXIB1; P450C11; RATCP11BA
Summary: Enables steroid 11-beta-monooxygenase activity and steroid binding activity. Involved in several processes, including cellular response to type II interferon; response to dexamethasone; and steroid hormone biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Used to study hypertension. Biomarker of brain infarction and hypertension. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 7q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (108653385..108660062, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (106772597..106780536, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that variations in intake of sodium and potassium act on expression of CYP11B2 in adrenal zona glomerulosa, but not on expression of CYP11B1.
Title: In vivo regulation of gene expression of enzymes controlling aldosterone synthesis in rat adrenal.
This study confirms transcription of CYP11B1 and CYP11B2 throughout central nervous system and demonstrates that gene transcription is subject to differential regulation by ACTH and circulating corticosteroid levels.
Title: Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system.
11beta-hydroxylase and aldosterone synthase are present within primary cultures of fetal rat hippocampal neurons
Title: 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons.
Cardiac CYP11B1 and CYP11B2 mRNA transcript levels from all in vivo and in vitro groups were never greater than 100 copies per microgram total RNA and therefore too low to be detected reproducibly.
Title: The aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart.

Submit: New GeneRIF Correction

General gene information

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Markers

D7Wox19 (e-PCR)
- UniSTS:118085

D7Wox18 (e-PCR)
- UniSTS:119228

D7Wox16 (e-PCR)
- UniSTS:119235

D7Mco7 (e-PCR)
- UniSTS:240606

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables corticosterone 18-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticosterone 18-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables steroid 11-beta-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid 11-beta-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid 11-beta-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adenosine metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in aldosterone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aldosterone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to peptide hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortisol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortisol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dibenzo-p-dioxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucocorticoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucocorticoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucocorticoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 11B1, mitochondrial

Names: Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); P450(11 beta)-DS; aldosterone synthase; cytochrome P450 11B1, mitochondrial-like; cytochrome P450(11 beta)-DS; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450C11; steroid 11-beta-hydroxylase, CYP11B1

NP_036669.3

EC 1.14.15.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012537.4 → NP_036669.3 cytochrome P450 11B1, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P15393, Q64655

UniProtKB/TrEMBL

A0A0G2K9N5, A0A0G2QC14

Related

ENSRNOP00000062325.4, ENSRNOT00000068707.5

Conserved Domains (1) summary

pfam00067
Location:42 → 495

p450; Cytochrome P450