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    Tpmt thiopurine S-methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690050, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tpmtprovided by RGD
    Official Full Name
    thiopurine S-methyltransferaseprovided by RGD
    Primary source
    RGD:1585162
    See related
    EnsemblRapid:ENSRNOG00000016468 AllianceGenome:RGD:1585162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable S-adenosyl-L-methionine binding activity and thiopurine S-methyltransferase activity. Involved in response to testosterone. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and poor metabolism of thiopurines 1. Orthologous to human TPMT (thiopurine S-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 393.7), Liver (RPKM 196.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpmt in Genome Data Viewer
    Location:
    17p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (17850308..17868976)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (17644088..17662709)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (18029090..18047716)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene DEK proto-oncogene Neighboring gene lysine demethylase 1B Neighboring gene NLR family, pyrin domain containing 4E like, pseudogene 1 Neighboring gene NHL repeat containing E3 ubiquitin protein ligase 1 Neighboring gene NFKB inhibitor interacting Ras-like 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Thiopurine methyltransferase genotyping in Palestinian childhood acute lymphoblastic leukemia patients. Ayesh BM, et al. BMC Hematol, 2013 Apr 10. PMID 24499706, Free PMC Article
    2. Thiopurine methyltransferase regulation in rat kidney: immunoprecipitation studies. Hernández JS, et al. Xenobiotica, 1991 Apr. PMID 1897245
    3. Effect of S-adenosylhomocysteine on sulfhydryl xenobiotic transmethylases in rat liver. Loo G, et al. Biochem Biophys Res Commun, 1985 Apr 30. PMID 3994729
    4. Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients. Gisbert JP, et al. Am J Gastroenterol, 2006 Dec. PMID 17026564
    5. Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus. Chen D, et al. Clin Rheumatol, 2014 Apr. PMID 24322830

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Munster protocols.
      Title: Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thiopurine S-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiopurine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiopurine S-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to testosterone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thiopurine S-methyltransferase
    Names
    thiopurine methyltransferase
    NP_001382599.1
    XP_038952015.1
    XP_038952016.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395670.1 → NP_001382599.1  thiopurine S-methyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q9Z0T0
      UniProtKB/TrEMBL
      A0A0G2K2B6, B0BMT6
      Related
      ENSRNOP00000022084.7, ENSRNOT00000022085.8
      Conserved Domains (1) summary
      pfam05724
      Location:19 → 240
      TPMT; Thiopurine S-methyltransferase (TPMT)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      17850308..17868976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096087.2 → XP_038952015.1  thiopurine S-methyltransferase isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:19 → 135
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_039096088.2 → XP_038952016.1  thiopurine S-methyltransferase isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:19 → 135
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001079531.1: Suppressed sequence

      Description
      NM_001079531.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0T0.1 GenPept UniProtKB/Swiss-Prot:Q9Z0T0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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