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    Spart spartin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295053, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Spartprovided by RGD
    Official Full Name
    spartinprovided by RGD
    Primary source
    RGD:1305900
    See related
    EnsemblRapid:ENSRNOG00000014155 AllianceGenome:RGD:1305900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spg20
    Summary
    Predicted to enable lipid binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including lipophagy; midbody abscission; and negative regulation of BMP signaling pathway. Predicted to act upstream of or within several processes, including adipose tissue development; lipid droplet organization; and negative regulation of collateral sprouting in absence of injury. Predicted to be located in several cellular components, including lipid droplet; midbody; and mitochondrial outer membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Troyer syndrome. Orthologous to human SPART (spartin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 137.7), Muscle (RPKM 103.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spart in Genome Data Viewer
    Location:
    2q26
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141442770..141469388)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (139292630..139319248)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (144522382..144548968)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene cyclin A1 Neighboring gene uncharacterized LOC134485736 Neighboring gene uncharacterized LOC134485916 Neighboring gene coiled-coil domain containing 169 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 2 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis. Joshi DC, et al. PLoS One, 2011 Apr 29. PMID 21559443, Free PMC Article
    2. Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Renvoisé B, et al. Hum Mol Genet, 2012 Aug 15. PMID 22619377, Free PMC Article
    3. Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. Edwards TL, et al. Biochem J, 2009 Sep 14. PMID 19580544, Free PMC Article
    4. SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Renvoisé B, et al. Mol Biol Cell, 2010 Oct 1. PMID 20719964, Free PMC Article
    5. Spartin recruits PKC-ζ via the PKC-ζ-interacting proteins ZIP1 and ZIP3 to lipid droplets. Urbanczyk A, et al. J Neurochem, 2011 Sep. PMID 21707618

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of collateral sprouting in absence of injury ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in midbody abscission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of collateral sprouting in absence of injury ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spartin
    Names
    spastic paraplegia 20 (Troyer syndrome) homolog
    spastic paraplegia 20, spartin (Troyer syndrome) homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106433.3 → NP_001099903.3  spartin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6JVE5
      Related
      ENSRNOP00000078817.1, ENSRNOT00000116850.2
      Conserved Domains (2) summary
      cd02679
      Location:16 → 95
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam06911
      Location:434 → 618
      Senescence; Senescence-associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      141442770..141469388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232367.5 → XP_006232429.2  spartin isoform X3

      UniProtKB/TrEMBL
      A6JVE5
      Conserved Domains (2) summary
      cd02679
      Location:16 → 95
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam06911
      Location:434 → 618
      Senescence; Senescence-associated protein

    2. XM_006232365.5 → XP_006232427.2  spartin isoform X1

      UniProtKB/TrEMBL
      A6JVE5
      Conserved Domains (2) summary
      cd02679
      Location:27 → 106
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam06911
      Location:445 → 629
      Senescence; Senescence-associated protein

    3. XM_006232366.5 → XP_006232428.2  spartin isoform X2

      UniProtKB/TrEMBL
      A6JVE5
      Related
      ENSRNOP00000054787.6, ENSRNOT00000057978.6
      Conserved Domains (2) summary
      cd02679
      Location:24 → 103
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam06911
      Location:442 → 626
      Senescence; Senescence-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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