Srd5a3 steroid 5 alpha-reductase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Srd5a3provided by RGD
Official Full Name: steroid 5 alpha-reductase 3provided by RGD
Primary source: RGD:1308828
See related: EnsemblRapid:ENSRNOG00000002216 AllianceGenome:RGD:1308828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S5AR 3; RGD1308828
Summary: Predicted to enable 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity; polyprenal reductase activity; and polyprenol reductase activity. Predicted to be involved in dolichol biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; and polyprenol catabolic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Kahrizi syndrome and congenital disorder of glycosylation Iq. Orthologous to human SRD5A3 (steroid 5 alpha-reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 50.1), Lung (RPKM 35.6) and 9 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (32400603..32414987, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (32046408..32060796, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (34554769..34570423, complement)

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	ISS Inferred from Sequence or Structural Similarity more info
enables polyprenal reductase activity	IEA Inferred from Electronic Annotation more info
enables polyprenal reductase activity	ISO Inferred from Sequence Orthology more info
enables polyprenal reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables polyprenol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables polyprenol reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dolichol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dolichol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in dolichol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in dolichol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in polyprenol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in polyprenol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in polyprenol catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polyprenal reductase; polyprenol reductase

Names: 3-oxo-5-alpha-steroid 4-dehydrogenase 3; SR type 3; probable polyprenol reductase

NP_001014012.1

EC 1.3.1.22

EC 1.3.1.94

NP_001388362.1

EC 1.3.1.22

EC 1.3.1.94

XP_038947815.1

EC 1.3.1.22

EC 1.3.1.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013990.1 → NP_001014012.1 polyprenal reductase isoform 1

See identical proteins and their annotated locations for NP_001014012.1

Status: VALIDATED

Source sequence(s)

BC086584

UniProtKB/TrEMBL

A0A140TAI0

Related

ENSRNOP00000056514.4, ENSRNOT00000059763.5

Conserved Domains (1) summary

cl21511
Location:51 → 262

PEMT; Phospholipid methyltransferase
NM_001401433.1 → NP_001388362.1 polyprenal reductase isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

D3ZUS5, D4A5U7, Q5RJM1

UniProtKB/TrEMBL

A0A0G2JSH3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

32400603..32414987 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091887.2 → XP_038947815.1 polyprenol reductase isoform X1

UniProtKB/Swiss-Prot

D3ZUS5, D4A5U7, Q5RJM1

UniProtKB/TrEMBL

A0A0G2JSH3

Related

ENSRNOP00000003021.4, ENSRNOT00000003021.8

Conserved Domains (1) summary

cl21511
Location:51 → 329

PEMT; Phospholipid methyltransferase