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    Eif4e2 eukaryotic translation initiation factor 4E family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363275, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Eif4e2provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4E family member 2provided by RGD
    Primary source
    RGD:1307790
    See related
    EnsemblRapid:ENSRNOG00000019634 AllianceGenome:RGD:1307790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eif4el3
    Summary
    Predicted to enable RNA 7-methylguanosine cap binding activity; mRNA cap binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of translational initiation; negative regulation of type I interferon-mediated signaling pathway; and rescue of stalled ribosome. Predicted to act upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to act upstream of or within in utero embryonic development and negative regulation of translation. Predicted to be located in P-body. Orthologous to human EIF4E2 (eukaryotic translation initiation factor 4E family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 165.9), Spleen (RPKM 140.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif4e2 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95333439..95362366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87886126..87914470)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94310476..94325445)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cholinergic receptor nicotinic delta subunit Neighboring gene cholinergic receptor nicotinic gamma subunit Neighboring gene U6 spliceosomal RNA Neighboring gene EF-hand domain family, member D1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms. Rosettani P, et al. J Mol Biol, 2007 May 4. PMID 17368478
    2. Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP. Tan NG, et al. FEBS Lett, 2003 Nov 20. PMID 14623119
    3. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Morita M, et al. Mol Cell Biol, 2012 Sep. PMID 22751931, Free PMC Article
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E type 2
    Names
    eukaryotic translation initiation factor 4E like 3
    eukaryotic translation initiation factor 4E member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402203.1 → NP_001389132.1  eukaryotic translation initiation factor 4E type 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5YC42, B0BNH0
      Related
      ENSRNOP00000077974.2, ENSRNOT00000114104.2

    2. NM_001402204.1 → NP_001389133.1  eukaryotic translation initiation factor 4E type 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5YC42, F1M470
      Related
      ENSRNOP00000075858.3, ENSRNOT00000092493.3

    3. NM_001402205.1 → NP_001389134.1  eukaryotic translation initiation factor 4E type 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0U1RRU1

    4. NM_001402206.1 → NP_001389135.1  eukaryotic translation initiation factor 4E type 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5YC42, A0A8I6AX14
      Related
      ENSRNOP00000074842.3, ENSRNOT00000085476.3

    5. NM_001402208.1 → NP_001389137.1  eukaryotic translation initiation factor 4E type 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5YC42, A0A8I6A0N7
      Related
      ENSRNOP00000085673.1, ENSRNOT00000094157.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      95333439..95362366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267448.1 → XP_063123518.1  eukaryotic translation initiation factor 4E type 2 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RRU1

    2. XM_063267449.1 → XP_063123519.1  eukaryotic translation initiation factor 4E type 2 isoform X2

      UniProtKB/TrEMBL
      A0A0U1RRU1
      Related
      ENSRNOP00000075812.2, ENSRNOT00000092534.3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108808.1: Suppressed sequence

      Description
      NM_001108808.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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