Pih1d1 PIH1 domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pih1d1provided by RGD
Official Full Name: PIH1 domain containing 1provided by RGD
Primary source: RGD:1309809
See related: EnsemblRapid:ENSRNOG00000020634 AllianceGenome:RGD:1309809
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309809
Summary: Predicted to enable several functions, including enzyme binding activity; histone reader activity; and phosphoprotein binding activity. Predicted to be involved in several processes, including positive regulation of signal transduction; protein-containing complex assembly; and regulation of primary metabolic process. Predicted to be located in nucleolus. Predicted to be part of R2TP complex; RPAP3/R2TP/prefoldin-like complex; and pre-snoRNP complex. Predicted to be active in cytoplasm. Orthologous to human PIH1D1 (PIH1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 52.0), Spleen (RPKM 51.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104774562..104781757)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95639597..95645295)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101151240..101156806)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137082 (e-PCR)
- UniSTS:219170

RH130045 (e-PCR)
- UniSTS:213333

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
NOT enables RNA polymerase I cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TORC1 complex assembly	ISO Inferred from Sequence Orthology more info
involved_in box C/D snoRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in box C/D snoRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in regulation of TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in snoRNA localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of R2TP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of R2TP complex	ISO Inferred from Sequence Orthology more info
part_of RPAP3/R2TP/prefoldin-like complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of pre-snoRNP complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PIH1 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024868.1 → NP_001020039.1 PIH1 domain-containing protein 1

See identical proteins and their annotated locations for NP_001020039.1

Status: PROVISIONAL

Source sequence(s)

BC097946

UniProtKB/Swiss-Prot

Q4V7F5

UniProtKB/TrEMBL

A0A8L2QF15

Conserved Domains (2) summary

pfam18201
Location:215 → 286

PIH1_CS; PIH1 CS-like domain

cl00175
Location:33 → 180

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104774562..104781757

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284179.1 → XP_063140249.1 PIH1 domain-containing protein 1 isoform X1
XM_006229027.4 → XP_006229089.1 PIH1 domain-containing protein 1 isoform X2

See identical proteins and their annotated locations for XP_006229089.1

UniProtKB/Swiss-Prot

Q4V7F5

UniProtKB/TrEMBL

A0A8L2QF15

Related

ENSRNOP00000089848.1, ENSRNOT00000119250.2

Conserved Domains (2) summary

pfam18201
Location:215 → 286

PIH1_CS; PIH1 CS-like domain

cl00175
Location:33 → 180

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.