Ccny cyclin Y [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccnyprovided by RGD
Official Full Name: cyclin Yprovided by RGD
Primary source: RGD:1565969
See related: EnsemblRapid:ENSRNOG00000018123 AllianceGenome:RGD:1565969
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565969
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of metabolic process; and regulation of canonical Wnt signaling pathway. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in plasma membrane. Orthologous to human CCNY (cyclin Y). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 345.4), Lung (RPKM 289.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (62079925..62207780, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (57385002..57512860, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (62332537..62462644, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCNY may be involved in hippocampal neuronal system
Title: Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons.
Data show that cyclin Y (CCNY) negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA receptor trafficking.
Title: Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137311 (e-PCR)
- UniSTS:219399

ha3046 (e-PCR)
- UniSTS:515632

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191833.1 → NP_001178762.1 cyclin-Y

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I5ZU57, F1MA89

Related

ENSRNOP00000082775.1, ENSRNOT00000099842.2

Conserved Domains (1) summary

pfam00134
Location:143 → 265

Cyclin_N; Cyclin, N-terminal domain