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    Tmx3 thioredoxin-related transmembrane protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682967, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tmx3provided by RGD
    Official Full Name
    thioredoxin-related transmembrane protein 3provided by RGD
    Primary source
    RGD:1592777
    See related
    EnsemblRapid:ENSRNOG00000045740 AllianceGenome:RGD:1592777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cell surface and endoplasmic reticulum. Orthologous to human TMX3 (thioredoxin related transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 172.7), Brain (RPKM 159.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmx3 in Genome Data Viewer
    Location:
    18q13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (86021137..86054025)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (83731777..83764719)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (87580227..87613481)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene docking protein 6 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene large ribosomal subunit protein eL32-like Neighboring gene zinc finger protein 950 like 16 Neighboring gene ribosomal protein S2, pseudogene 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. Haugstetter J, et al. J Biol Chem, 2005 Mar 4. PMID 15623505
    2. Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Holbrook LM, et al. Br J Haematol, 2010 Feb. PMID 19995400
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide-isomerase TMX3
    NP_001387727.1
    XP_038953304.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400798.1 → NP_001387727.1  protein disulfide-isomerase TMX3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6ARW7, A6K5P3, M0R402
      Related
      ENSRNOP00000064077.3, ENSRNOT00000070984.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      86021137..86054025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097376.2 → XP_038953304.1  protein disulfide-isomerase TMX3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARW7
      Conserved Domains (2) summary
      TIGR01130
      Location:1 → 275
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:1 → 61
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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