Mettl16 methyltransferase 16, RNA N6-adenosine [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl16provided by RGD
Official Full Name: methyltransferase 16, RNA N6-adenosineprovided by RGD
Primary source: RGD:1593242
See related: EnsemblRapid:ENSRNOG00000002764 AllianceGenome:RGD:1593242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mett10d
Summary: Predicted to enable RNA binding activity and RNA methyltransferase activity. Predicted to be involved in RNA metabolic process and regulation of mRNA metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 75.2), Adrenal (RPKM 69.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (60139317..60185438)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (59640915..59697291)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (61626595..61682947)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle.
Title: METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle.

Submit: New GeneRIF Correction

General gene information

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Markers

BE119243 (e-PCR)
- UniSTS:249135

RH141320 (e-PCR)
- UniSTS:223316

AW228947 (e-PCR)
- UniSTS:186097

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables U6 snRNA 3'-end binding	ISO Inferred from Sequence Orthology more info
enables mRNA m(6)A methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of S-adenosylmethionine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in rRNA base methylation	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in snRNA (adenine-N6)-methylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA N6-adenosine-methyltransferase METTL16

Names: methyltransferase 10 domain containing; methyltransferase 16, N6-methyladenosine; methyltransferase like 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402033.1 → NP_001388962.1 RNA N6-adenosine-methyltransferase METTL16

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZQX2, D3Z9M1

Related

ENSRNOP00000003750.7, ENSRNOT00000003750.10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

60139317..60185438

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_056984671.2 → XP_056840651.1 RNA N6-adenosine-methyltransferase METTL16 isoform X1

UniProtKB/TrEMBL

A0A8I5ZQX2, D3Z9M1
XM_056984673.2 → XP_056840653.1 RNA N6-adenosine-methyltransferase METTL16 isoform X2

UniProtKB/TrEMBL

D3Z9M1

Related

ENSRNOP00000097529.2, ENSRNOT00000107585.2
XM_056984675.2 → XP_056840655.1 RNA N6-adenosine-methyltransferase METTL16 isoform X3

UniProtKB/TrEMBL

A6HGN3