Ankle2 ankyrin repeat and LEM domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ankle2provided by RGD
Official Full Name: ankyrin repeat and LEM domain containing 2provided by RGD
Primary source: RGD:1310191
See related: EnsemblRapid:ENSRNOG00000060144 AllianceGenome:RGD:1310191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ab2-034; RGD1310191
Summary: Predicted to enable protein kinase inhibitor activity and protein phosphatase 2A binding activity. Predicted to be involved in several processes, including mitotic nuclear membrane reassembly; negative regulation of apoptotic process; and negative regulation of phosphorylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 178.0), Lung (RPKM 162.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (52077863..52110775, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (46418142..46451304, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (52475862..52507126, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic nuclear membrane reassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic nuclear membrane reassembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic nuclear membrane reassembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic nuclear membrane reassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ankyrin repeat and LEM domain-containing protein 2

Names: LEM domain-containing protein 4; liver regeneration-related protein LRRG057

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393843.2 → NP_001380772.1 ankyrin repeat and LEM domain-containing protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

F1LMJ0, F1M1M8, Q7TP65

Related

ENSRNOP00000095784.1, ENSRNOT00000101492.2

Conserved Domains (4) summary

COG5236
Location:37 → 184

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

cd12944
Location:74 → 116

LEM_ANKL2; LEM (Lap2/Emerin/Man1) domain found in ankyrin repeat and LEM domain-containing protein 2 (ANKL2)

sd00045
Location:419 → 452

ANK; ANK repeat [structural motif]

cl39094
Location:384 → 458

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

52077863..52110775 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769343.4 → XP_008767565.3 ankyrin repeat and LEM domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I6ANV5

Related

ENSRNOP00000107770.1, ENSRNOT00000130998.1

Conserved Domains (5) summary

COG5236
Location:171 → 318

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

cd12944
Location:208 → 250

LEM_ANKL2; LEM (Lap2/Emerin/Man1) domain found in ankyrin repeat and LEM domain-containing protein 2 (ANKL2)

sd00045
Location:552 → 585

ANK; ANK repeat [structural motif]

pfam01693
Location:360 → 391

Cauli_VI; Caulimovirus viroplasmin

cl39094
Location:517 → 591

Ank_2; Ankyrin repeats (3 copies)
XM_063271551.1 → XP_063127621.1 ankyrin repeat and LEM domain-containing protein 2 isoform X2

RNA

XR_005491651.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001047901.1: Suppressed sequence

Description

NM_001047901.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.