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    Marchf11 membrane associated ring-CH-type finger 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499558, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Marchf11provided by RGD
    Official Full Name
    membrane associated ring-CH-type finger 11provided by RGD
    Primary source
    RGD:1559945
    See related
    EnsemblRapid:ENSRNOG00000024461 AllianceGenome:RGD:1559945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    March11; MARCH-XI; RGD1559945
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasmic vesicle membrane and endomembrane system. Orthologous to human MARCHF11 (membrane associated ring-CH-type finger 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 450.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Marchf11 in Genome Data Viewer
    Location:
    2q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (78628793..78730164)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (76898330..76999690)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (78825053..78926402)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC134485864 Neighboring gene F-box and leucine-rich repeat protein 7 Neighboring gene uncharacterized LOC120100752 Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. Morokuma Y, et al. J Biol Chem, 2007 Aug 24. PMID 17604280
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MARCH-XI acts as a ubiquitin ligase with a role in ubiquitin-mediated protein sorting in the TGN-MVB transport pathway, which may be involved in mammalian spermiogenesis
      Title: MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF11
    Names
    E3 ubiquitin-protein ligase MARCH11
    RING-type E3 ubiquitin transferase MARCH11
    RING-type E3 ubiquitin transferase MARCHF11
    membrane-associated RING finger protein 11
    membrane-associated RING-CH protein XI
    membrane-associated ring finger (C3HC4) 11
    NP_001095298.1
    XP_017446509.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101828.1 → NP_001095298.1  E3 ubiquitin-protein ligase MARCHF11

      Status: VALIDATED

      Source sequence(s)
      AB048841, AW528861, CK596283
      UniProtKB/Swiss-Prot
      A6P320
      UniProtKB/TrEMBL
      F1LSY5
      Conserved Domains (1) summary
      cd16700
      Location:165 → 215
      RING_CH-C4HC3_MARCH4_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH4, MARCH9, MARCH11, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      78628793..78730164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591020.3 → XP_017446509.1  E3 ubiquitin-protein ligase MARCHF11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GB48
      Related
      ENSRNOP00000083775.1, ENSRNOT00000102916.2
      Conserved Domains (1) summary
      cd16810
      Location:164 → 215
      RING_CH-C4HC3_MARCH11; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH11 (MARCH11)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6P320.1 GenPept UniProtKB/Swiss-Prot:A6P320

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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