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    Tars3 threonyl-tRNA synthetase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308701, updated on 27-Dec-2024

    Summary

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    Symbol
    Tars3provided by RGD
    Full Name
    threonyl-tRNA synthetase 3provided by RGD
    Primary source
    RGD:1311308
    See related
    EnsemblRapid:ENSRNOG00000024460 AllianceGenome:RGD:1311308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tarsl2; RGD1311308
    Summary
    Predicted to enable threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. Orthologous to human TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 171.6), Muscle (RPKM 152.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tars3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (128623678..128675978)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (119213189..119265492)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (126523169..126559493)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546680 Neighboring gene uncharacterized LOC120099841 Neighboring gene TM2 domain containing 3 Neighboring gene uncharacterized LOC108349586 Neighboring gene uncharacterized LOC120099842

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities. Chen Y, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29579307, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in threonyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    threonine--tRNA ligase 2, cytoplasmic
    Names
    probable threonine--tRNA ligase 2, cytoplasmic
    probable threonyl-tRNA synthetase 2, cytoplasmic
    threonyl-tRNA synthetase-like 2
    NP_001388464.1
    XP_063118538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401535.1 → NP_001388464.1  threonine--tRNA ligase 2, cytoplasmic

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AAW1, A6JBN1, A6JBN2
      Related
      ENSRNOP00000090461.1, ENSRNOT00000110192.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      128623678..128675978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262468.1 → XP_063118538.1  threonine--tRNA ligase 2, cytoplasmic isoform X1

    RNA

    1. XR_005505558.2 RNA Sequence

    2. XR_005505557.2 RNA Sequence

      Related
      ENSRNOT00000051000.6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014020.1: Suppressed sequence

      Description
      NM_001014020.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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