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    Fam135a family with sequence similarity 135, member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367235, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fam135aprovided by RGD
    Official Full Name
    family with sequence similarity 135, member Aprovided by RGD
    Primary source
    RGD:1304927
    See related
    EnsemblRapid:ENSRNOG00000013587 AllianceGenome:RGD:1304927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304927
    Summary
    Predicted to be involved in lipid metabolic process. Orthologous to human FAM135A (family with sequence similarity 135 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 130.3), Kidney (RPKM 117.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam135a in Genome Data Viewer
    Location:
    9q13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (33916449..33997140, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (26420116..26500803, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (30255057..30335775, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small ArfGAP 1 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene uncharacterized LOC102553447 Neighboring gene collagen type IX alpha 1 chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM135A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134597.2 → NP_001128069.2  protein FAM135A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJB5, D3ZVB3
      Related
      ENSRNOP00000018234.7, ENSRNOT00000018234.9
      Conserved Domains (2) summary
      pfam05057
      Location:1243 → 1438
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    2. NM_001393818.1 → NP_001380747.1  protein FAM135A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1073 → 1268
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      33916449..33997140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267501.1 → XP_063123571.1  protein FAM135A isoform X3

      UniProtKB/TrEMBL
      A6JJB5

    2. XM_039083961.2 → XP_038939889.1  protein FAM135A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV8, A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1269 → 1464
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    3. XM_017596557.3 → XP_017452046.1  protein FAM135A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV8, A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1269 → 1464
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    4. XM_017596560.3 → XP_017452049.1  protein FAM135A isoform X4

      UniProtKB/TrEMBL
      A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1047 → 1242
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein of unknown function (DUF3657)

    5. XM_017596553.3 → XP_017452042.1  protein FAM135A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV8, A6JJB5
      Related
      ENSRNOP00000080690.1, ENSRNOT00000111990.2
      Conserved Domains (2) summary
      pfam05057
      Location:1269 → 1464
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    6. XM_063267502.1 → XP_063123572.1  protein FAM135A isoform X4

      UniProtKB/TrEMBL
      A6JJB5

    7. XM_017596554.3 → XP_017452043.1  protein FAM135A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV8, A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1269 → 1464
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    8. XM_063267499.1 → XP_063123569.1  protein FAM135A isoform X2

      UniProtKB/TrEMBL
      A6JJB5, D3ZVB3

    9. XM_063267500.1 → XP_063123570.1  protein FAM135A isoform X3

      UniProtKB/TrEMBL
      A6JJB5

    10. XM_006244664.4 → XP_006244726.1  protein FAM135A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV8, A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1269 → 1464
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    11. XM_017596556.3 → XP_017452045.1  protein FAM135A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV8, A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1269 → 1464
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    12. XM_039083960.2 → XP_038939888.1  protein FAM135A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV8, A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1269 → 1464
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    13. XM_017596555.3 → XP_017452044.1  protein FAM135A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV8, A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1269 → 1464
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    14. XM_039083959.2 → XP_038939887.1  protein FAM135A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV8, A6JJB5
      Conserved Domains (2) summary
      pfam05057
      Location:1269 → 1464
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111 → 171
      DUF3657; Protein FAM135

    15. XM_039083962.2 → XP_038939890.1  protein FAM135A isoform X5

      UniProtKB/TrEMBL
      A6JJB5
      Conserved Domains (1) summary
      pfam05057
      Location:991 → 1186
      DUF676; Putative serine esterase (DUF676)

    16. XM_039083963.2 → XP_038939891.1  protein FAM135A isoform X6

      UniProtKB/TrEMBL
      A6JJB5
      Conserved Domains (1) summary
      pfam05057
      Location:967 → 1162
      DUF676; Putative serine esterase (DUF676)

    17. XM_039083965.2 → XP_038939893.1  protein FAM135A isoform X8

      Conserved Domains (1) summary
      pfam05057
      Location:818 → 1013
      DUF676; Putative serine esterase (DUF676)

    18. XM_039083964.2 → XP_038939892.1  protein FAM135A isoform X7

      Conserved Domains (1) summary
      pfam05057
      Location:849 → 1044
      DUF676; Putative serine esterase (DUF676)

    19. XM_039083966.2 → XP_038939894.1  protein FAM135A isoform X9

      Conserved Domains (1) summary
      pfam05057
      Location:653 → 848
      DUF676; Putative serine esterase (DUF676)
    Nucleotide Protein Strain
    Heading Accession and Version

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