Kcnk6 potassium two pore domain channel subfamily K member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Kcnk6provided by RGD
Full Name: potassium two pore domain channel subfamily K member 6provided by RGD
Primary source: RGD:621450
See related: AllianceGenome:RGD:621450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Twik2; Twik-2
Summary: Enables potassium channel activity. Involved in regulation of lysosome size. Located in late endosome membrane and lysosomal membrane. Biomarker of brain infarction. Orthologous to human KCNK6 (potassium two pore domain channel subfamily K member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 95.3), Spleen (RPKM 73.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (93652888..93661419, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (84525613..84533948, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (88168438..88176610, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although K(2P) channels are highly expressed, K(2P) currents are not activated via the NO/cGMP pathway in rat middle cerebral artery smooth muscle, despite the presence of numerous putative PKG phosphorylation sites
Title: cGMP does not activate two-pore domain K+ channels in cerebrovascular smooth muscle.
K(2P)6.1 (TWIK 2) immunoreactivity was detected in nerve terminals, blood vessels hair cells and transitional cells of the crista ampullaris and in the somata and neuron fibers of Scarpa's ganglia.
Title: Distribution of two-pore-domain potassium channels in the adult rat vestibular periphery.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lysosome size	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of resting membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium channel subfamily K member 6

Names: potassium channel subfamily K member 6-like; potassium channel, subfamily K, member 6; potassium channel, two pore domain subfamily K, member 6; potassium inwardly-rectifying channel, subfamily K, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053806.2 → NP_446258.2 potassium channel subfamily K member 6

See identical proteins and their annotated locations for NP_446258.2

Status: VALIDATED

Source sequence(s)

AF281304, BF405813, JAXUCZ010000001

UniProtKB/Swiss-Prot

G3V8R8, Q9ERU4, Q9ERU5

UniProtKB/TrEMBL

A6J9P6

Conserved Domains (1) summary

pfam07885
Location:180 → 259

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

93652888..93661419 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109467.2 → XP_038965395.1 potassium channel subfamily K member 6 isoform X1

Conserved Domains (1) summary

pfam07885
Location:46 → 125

Ion_trans_2; Ion channel
XM_039109439.2 → XP_038965367.1 potassium channel subfamily K member 6 isoform X1

Conserved Domains (1) summary

pfam07885
Location:46 → 125

Ion_trans_2; Ion channel
XM_039109523.2 → XP_038965451.1 potassium channel subfamily K member 6 isoform X1

Conserved Domains (1) summary

pfam07885
Location:46 → 125

Ion_trans_2; Ion channel