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    Adarb2 adenosine deaminase RNA specific B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117088, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Adarb2provided by RGD
    Official Full Name
    adenosine deaminase RNA specific B2provided by RGD
    Primary source
    RGD:621519
    See related
    EnsemblRapid:ENSRNOG00000030775 AllianceGenome:RGD:621519
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Red2; Adar3
    Summary
    Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ADARB2 (adenosine deaminase RNA specific B2 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 61.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adarb2 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (66660586..67211104, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (61750437..62300984, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (58098979..58653137, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482867 Neighboring gene WD repeat domain 37 Neighboring gene isopentenyl-diphosphate delta isomerase 1 Neighboring gene uncharacterized LOC134482734 Neighboring gene uncharacterized LOC102552293 Neighboring gene elongin B like 1 Neighboring gene uncharacterized LOC134482780 Neighboring gene uncharacterized LOC134482781

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RED2, a brain-specific member of the RNA-specific adenosine deaminase family. Melcher T, et al. J Biol Chem, 1996 Dec 13. PMID 8943218
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    double-stranded RNA-specific editase B2
    Names
    RNA-dependent adenosine deaminase 3
    RNA-editing deaminase 2
    RNA-editing enzyme 2
    adenosine deaminase 3, RNA dependent
    dsRNA adenosine deaminase B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133302.2 → NP_579836.1  double-stranded RNA-specific editase B2

      See identical proteins and their annotated locations for NP_579836.1

      Status: PROVISIONAL

      Source sequence(s)
      U74586
      UniProtKB/Swiss-Prot
      P97616
      UniProtKB/TrEMBL
      A6KRP0, F1LSW5
      Related
      ENSRNOP00000047468.6, ENSRNOT00000047512.6
      Conserved Domains (3) summary
      smart00358
      Location:285 → 332
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:367 → 743
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:126 → 190
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      66660586..67211104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095307.2 → XP_038951235.1  double-stranded RNA-specific editase B2 isoform X2

      UniProtKB/TrEMBL
      A6KRP0, F1LSW5
      Conserved Domains (3) summary
      cd19896
      Location:123 → 196
      DSRM_RED2_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 2 (RED2) and similar proteins
      cl00054
      Location:277 → 350
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
      cl02661
      Location:367 → 636
      A_deamin; Adenosine-deaminase (editase) domain

    2. XM_017600442.3 → XP_017455931.2  double-stranded RNA-specific editase B2 isoform X1

      UniProtKB/TrEMBL
      A6KRP0, F1LSW5
      Related
      ENSRNOP00000110240.1, ENSRNOT00000157779.1
      Conserved Domains (3) summary
      smart00552
      Location:367 → 688
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19896
      Location:123 → 196
      DSRM_RED2_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 2 (RED2) and similar proteins
      cl00054
      Location:277 → 350
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97616.1 GenPept UniProtKB/Swiss-Prot:P97616

    Gene LinkOut

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