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Plcg2 phospholipase C, gamma 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29337, updated on 27-Dec-2024

Summary

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Official Symbol: Plcg2provided by RGD
Official Full Name: phospholipase C, gamma 2provided by RGD
Primary source: RGD:3348
See related: EnsemblRapid:ENSRNOG00000051986 AllianceGenome:RGD:3348
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables phosphatidylinositol phospholipase C activity. Involved in several processes, including positive regulation of DNA-binding transcription factor activity; positive regulation of cell cycle G1/S phase transition; and response to ATP. Predicted to be located in several cellular components, including cytosol; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in ruffle membrane. Human ortholog(s) of this gene implicated in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 196.8), Thymus (RPKM 52.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Plcg2 in Genome Data Viewer

Location:: 19q12

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (62456196..62592684)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (45547416..45683930)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (50039410..50173543)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLCG2 plays an important role in rat liver cell proliferation via ERK and NF-kappaB pathway by regulating the expression of BCl2, MYC and CCND1
Title: PLCG2 promotes hepatocyte proliferation in vitro via NF-κB and ERK pathway by targeting bcl2, myc and ccnd1.
these findings suggest that interference with PLCgamma2 expression could relieve the inhibitory effect of PLCgamma2 on hepaocyte apoptosis, thus, promote proliferation through inactivating PKCdelta-mediated JNK1/2 signaling pathway.
Title: Silencing of phospholipase C gamma 2 promotes proliferation of rat hepatocytes in vitro.
PLCgamma2 regulates hepatocyte growth through PKCD-dependently activating p38 MAPK and JNK MAPK pathways
Title: PLCγ2 promotes apoptosis while inhibits proliferation in rat hepatocytes through PKCD/JNK MAPK and PKCD/p38 MAPK signalling.
These results show that a recombinant adenovirus, Ad-PLCg2-shRNA, was developed and was effective at silencing the rat PLCg2 gene. This construct may contribute to the study of PLCg2 in hepatocyte apoptosis during liver regeneration
Title: Construction of recombinant adenovirus Ad-rat PLCg2-shRNA and successful suppression of PLCg2 expression in BRL-3A cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Plcg2 (e-PCR), detects polymorphism
- UniSTS:532521

RH94702 (e-PCR)
- UniSTS:119949

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phosphorylation-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables phosphorylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
involved_in antifungal innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antifungal innate immune response	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell activation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lectin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipid	ISO Inferred from Sequence Orthology more info
involved_in follicular B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within follicular B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inositol trisphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inositol trisphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle G1/S phase transition	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-23 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-23 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuroinflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in programmed cell death	IEA Inferred from Electronic Annotation more info
acts_upstream_of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ATP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to magnesium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to yeast	IEA Inferred from Electronic Annotation more info
involved_in response to yeast	ISO Inferred from Sequence Orthology more info
involved_in stimulatory C-type lectin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in stimulatory C-type lectin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular vesicle	IEA Inferred from Electronic Annotation more info
located_in intracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
is_active_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Names: PLC-IV; PLC-gamma-2; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-2; phospholipase C-IV

NP_058864.1

EC 3.1.4.11

XP_038953601.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017168.1 → NP_058864.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

See identical proteins and their annotated locations for NP_058864.1

Status: PROVISIONAL

Source sequence(s)

J05155

UniProtKB/Swiss-Prot

P24135

UniProtKB/TrEMBL

A0A0G2JWA2, A6IZH5

Related

ENSRNOP00000069801.2, ENSRNOT00000090165.3

Conserved Domains (9) summary

cd00275
Location:1061 → 1187

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08592
Location:311 → 458

PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma

cd09932
Location:641 → 744

SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma

cd10341
Location:527 → 627

SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma

cd11969
Location:773 → 827

SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2

cd13234
Location:840 → 910

PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain

cd13362
Location:22 → 140

PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain

cl14615
Location:926 → 1031

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

cl17171
Location:475 → 510

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

62456196..62592684

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097673.2 → XP_038953601.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

UniProtKB/TrEMBL

A0A0G2JWA2, A6IZH5

Conserved Domains (9) summary

cd00275
Location:994 → 1120

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08592
Location:244 → 391

PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma

cd09932
Location:574 → 677

SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma

cd10341
Location:460 → 560

SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma

cd11969
Location:706 → 760

SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2

cd13234
Location:773 → 843

PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain

cd16215
Location:78 → 231

EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

cl14615
Location:859 → 964

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

cl17171
Location:1 → 73

PH-like; Pleckstrin homology-like domain