P2rx3 purinergic receptor P2X 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P2rx3provided by RGD
Official Full Name: purinergic receptor P2X 3provided by RGD
Primary source: RGD:620253
See related: EnsemblRapid:ENSRNOG00000008552 AllianceGenome:RGD:620253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including ATP binding activity; extracellularly ATP-gated monoatomic cation channel activity; and identical protein binding activity. Involved in several processes, including behavioral response to formalin induced pain; cellular response to ATP; and neuronal action potential. Located in several cellular components, including dendritic spine; neuronal cell body; and terminal bouton. Is active in presynaptic membrane. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 11.6), Adrenal (RPKM 5.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (90487506..90531315, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (70080850..70124664, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (72403992..72447801, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP27 Modulates Neuropathic Pain by Inhibiting P2X3 Degradation.
Title: HSP27 Modulates Neuropathic Pain by Inhibiting P2X3 Degradation.
miR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats.
Title: miR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats.
[Effect of electroacupuncture on the expressions of TRPV1, P2X3 receptors in bladder of rats with interstitial cystitis].
Title: [Effect of electroacupuncture on the expressions of TRPV1, P2X3 receptors in bladder of rats with interstitial cystitis].
Estrogen inhibits bladder overactivity in rats with cyclophosphamide-induced cystitis via downregulating the expression of P2X3 receptors in bladder epithelium cells.
Title: Estrogen inhibits bladder overactivity in rats with cyclophosphamide-induced cystitis via downregulating the expression of P2X3 receptors in bladder epithelium cells.
P2X3 receptor upregulation in trigeminal ganglion neurons through TNFalpha production in macrophages contributes to trigeminal neuropathic pain in rats.
Title: P2X(3) receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats.
P2X3 and P2X2/3 receptors activation induces articular hyperalgesia by an indirect sensitization of the primary afferent nociceptor in the rats' knee joint.
Title: P2X3 and P2X2/3 receptors activation induces articular hyperalgesia by an indirect sensitization of the primary afferent nociceptor in the rats' knee joint.
Gene expression profile of the hippocampus of rats subjected to traumatic brain injury.
Title: Gene expression profile of the hippocampus of rats subjected to traumatic brain injury.
our results indicated that 2 Hz Electroacupuncture (EA) was an effective method for treating heroin-induced hyperalgesia and helping prevent relapse, and the potential mechanism might be related to the downregulation of P2X3 receptor expression in the dorsal root ganglia
Title: 2 Hz EA Reduces Heroin Withdrawal-Induced Hyperalgesia and Heroin Relapse by Downregulating P2X3 Receptors in DRG Neurons.
These findings demonstrated that mechanical muscle hyperalgesia and neutrophil migration induced by static contraction are modulated by P2X3 receptors
Title: P2X3 receptors contribute to muscle pain induced by static contraction by a mechanism dependent on neutrophil migration.
This result indicated that electroacupuncture reduced pain hypersensitivity through Purinergic receptor P2X3 modulation.
Title: Electroacupuncture Stimulation Alleviates CFA-Induced Inflammatory Pain Via Suppressing P2X3 Expression.

Submit: New GeneRIF Correction See all GeneRIFs (95)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables purinergic nucleotide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables purinergic nucleotide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in behavioral response to formalin induced pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral response to pain	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ATP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to ATP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ATP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in peristalsis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peristalsis	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to carbohydrate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to carbohydrate	ISO Inferred from Sequence Orthology more info
involved_in response to cold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to temperature stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of taste	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of taste	ISO Inferred from Sequence Orthology more info
involved_in urinary bladder smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urinary bladder smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P2X purinoceptor 3

Names: ATP receptor; P2X3; purinergic receptor P2X, ligand-gated ion channel, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270621.2 → NP_001257550.1 P2X purinoceptor 3 isoform 2

See identical proteins and their annotated locations for NP_001257550.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2K147, Q9R1K3

Related

ENSRNOP00000071698.3, ENSRNOT00000077573.3

Conserved Domains (1) summary

pfam00864
Location:8 → 339

P2X_receptor; ATP P2X receptor
NM_031075.3 → NP_112337.2 P2X purinoceptor 3 isoform 1

See identical proteins and their annotated locations for NP_112337.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P49654

UniProtKB/TrEMBL

A6HMS8, Q66HM4

Related

ENSRNOP00000106307.1, ENSRNOT00000158499.1

Conserved Domains (1) summary

pfam00864
Location:8 → 363

P2X_receptor; ATP P2X receptor

RNA

NR_073054.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs at the 5' end and at the 3' end of an internal exon compared to variant 1. The 5' end of the resulting transcript has an ORF with a strong Kozak signal, making this transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, it is unlikely that this transcript encodes a protein.

Source sequence(s)

BC081783, CB715302, JAXUCZ010000003