Dhps deoxyhypusine synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhpsprovided by RGD
Official Full Name: deoxyhypusine synthaseprovided by RGD
Primary source: RGD:1303326
See related: EnsemblRapid:ENSRNOG00000004219 AllianceGenome:RGD:1303326
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables deoxyhypusine synthase activity and identical protein binding activity. Involved in spermidine catabolic process. Predicted to be active in cytosol. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 195.8), Muscle (RPKM 182.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (39987328..39991418, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23082454..23086544, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (26184665..26188755)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables deoxyhypusine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyhypusine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables deoxyhypusine synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-lysine modification to peptidyl-hypusine	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine modification to peptidyl-hypusine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in spermidine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermidine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: deoxyhypusine synthase

Names: DHS

NP_001004207.1

EC 2.5.1.46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.