U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Rps6kb1 ribosomal protein S6 kinase B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83840, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rps6kb1provided by RGD
    Official Full Name
    ribosomal protein S6 kinase B1provided by RGD
    Primary source
    RGD:620683
    See related
    EnsemblRapid:ENSRNOG00000003919 AllianceGenome:RGD:620683
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p70 S6K-alpha
    Summary
    Enables several functions, including ATP binding activity; PDZ domain binding activity; and protein phosphatase 2A binding activity. Involved in several processes, including long-term memory; positive regulation of skeletal muscle tissue growth; and skeletal muscle atrophy. Located in cell surface and perinuclear region of cytoplasm. Is active in postsynapse. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hyperinsulinism; muscular atrophy; obesity; and primary biliary cholangitis. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 160.2), Thymus (RPKM 146.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rps6kb1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (71817794..71865211, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (71323777..71367908, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (73824200..73865503, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095332 Neighboring gene U6 spliceosomal RNA Neighboring gene ring finger protein, transmembrane 1 Neighboring gene tubulin, delta 1 Neighboring gene microRNA 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 34
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables PDZ domain binding PubMed 
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding PubMed 
    enables peptide binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein phosphatase 2A binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine/tyrosine kinase activity  
    enables ribosomal protein S6 kinase activity PubMed 
    Items 1 - 25 of 34
    Items 1 - 25 of 65
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle  
    involved_in TOR signaling  
    involved_in TOR signaling  
    involved_in TORC1 signaling  
    involved_in apoptotic process  
    acts_upstream_of_or_within behavioral fear response  
    involved_in cell migration PubMed 
    acts_upstream_of_or_within cellular response to dexamethasone stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to hormone stimulus PubMed 
    involved_in cellular response to insulin stimulus  
    acts_upstream_of_or_within cellular response to insulin stimulus  
    involved_in cellular response to nutrient  
    acts_upstream_of_or_within cellular response to organic cyclic compound  
    involved_in cellular response to type II interferon  
    involved_in chromatin remodeling  
    acts_upstream_of_or_within germ cell development  
    involved_in long-chain fatty acid import into cell  
    involved_in long-chain fatty acid import into cell  
    involved_in long-term memory PubMed 
    involved_in modulation of chemical synaptic transmission  
    involved_in negative regulation of TORC2 signaling  
    involved_in negative regulation of TORC2 signaling  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of insulin receptor signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway  
    involved_in negative regulation of insulin receptor signaling pathway  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of mitotic cell cycle  
    involved_in positive regulation of skeletal muscle tissue growth PubMed 
    involved_in positive regulation of smooth muscle cell migration PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of translation  
    involved_in positive regulation of translational initiation  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in regulation of D-glucose import PubMed 
    involved_in response to L-leucine PubMed 
    involved_in response to amino acid PubMed 
    involved_in response to electrical stimulus involved in regulation of muscle adaptation PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to glucagon PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to glucose PubMed 
    involved_in response to insulin PubMed 
    involved_in response to insulin PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in response to methamphetamine hydrochloride PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to nutrient levels  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in response to testosterone PubMed 
    involved_in response to toxic substance PubMed 
    involved_in response to tumor necrosis factor PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in signal transduction  
    involved_in skeletal muscle atrophy PubMed 
    involved_in skeletal muscle contraction PubMed 
    Items 1 - 25 of 65
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in glutamatergic synapse  
    located_in mitochondrial outer membrane  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in neuron projection  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in postsynapse PubMed 
    is_active_in synapse PubMed 
    located_in synapse  

    General protein information

    Preferred Names
    ribosomal protein S6 kinase beta-1
    Names
    70 kDa ribosomal protein S6 kinase 1
    P70S6K
    P70S6K1
    S6 kinase
    S6K
    S6K-beta-1
    S6K1
    p70 S6 kinase alpha
    p70 S6KA
    p70 ribosomal S6 kinase alpha
    p70(S6K)-alpha
    p70-S6K 1
    ribosomal protein S6 kinase I
    ribosomal protein S6 kinase, 70kDa, polypeptide 1
    ribosomal protein S6 kinase, polypeptide 1
    NP_114191.1
    XP_006247173.1
    XP_063126049.1
    XP_063126050.1
    XP_063126051.1
    XP_063126052.1
    XP_063126053.1
    XP_063126054.1
    XP_063126055.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031985.1NP_114191.1  ribosomal protein S6 kinase beta-1

      See identical proteins and their annotated locations for NP_114191.1

      Status: PROVISIONAL

      Source sequence(s)
      M58340
      UniProtKB/Swiss-Prot
      P67999
      Related
      ENSRNOP00000111651.1, ENSRNOT00000122089.1
      Conserved Domains (2) summary
      smart00220
      Location:91352
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05584
      Location:94416
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      71817794..71865211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269982.1XP_063126052.1  ribosomal protein S6 kinase beta-1 isoform X4

      UniProtKB/Swiss-Prot
      P67999
      Related
      ENSRNOP00000102550.1, ENSRNOT00000157804.1
    2. XM_006247111.5XP_006247173.1  ribosomal protein S6 kinase beta-1 isoform X5

      UniProtKB/Swiss-Prot
      P67999
      Related
      ENSRNOP00000078345.2, ENSRNOT00000118202.2
      Conserved Domains (2) summary
      smart00220
      Location:91352
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05584
      Location:94416
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
    3. XM_063269980.1XP_063126050.1  ribosomal protein S6 kinase beta-1 isoform X2

    4. XM_063269979.1XP_063126049.1  ribosomal protein S6 kinase beta-1 isoform X1

      UniProtKB/Swiss-Prot
      P67999
    5. XM_063269981.1XP_063126051.1  ribosomal protein S6 kinase beta-1 isoform X3

    6. XM_063269983.1XP_063126053.1  ribosomal protein S6 kinase beta-1 isoform X6

    7. XM_063269985.1XP_063126055.1  ribosomal protein S6 kinase beta-1 isoform X8

    8. XM_063269984.1XP_063126054.1  ribosomal protein S6 kinase beta-1 isoform X7

    RNA

    1. XR_005489956.2 RNA Sequence

    2. XR_010055269.1 RNA Sequence

    3. XR_010055270.1 RNA Sequence

    External link. Please review our privacy policy.