Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2f4provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily f, polypeptide 4provided by RGD
Primary source: RGD:2476
See related: EnsemblRapid:ENSRNOG00000032805 AllianceGenome:RGD:2476
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp2f1; Cyp2f2; CYP4502F4
Summary: Enables monooxygenase activity. Involved in trichloroethylene metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human CYP2F1 (cytochrome P450 family 2 subfamily F member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 268.0), Liver (RPKM 139.3) and 1 other tissue See more
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Genomic context

Location:: 1q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (91543768..91557553)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (82416107..82429897)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (83933974..83947804)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

G67797 (e-PCR)
- UniSTS:225573

RH94438 (e-PCR)
- UniSTS:119686

Cyp2f2 (e-PCR), detects polymorphism
- UniSTS:499084

Cyp2f2 (e-PCR), detects polymorphism
- UniSTS:462997

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within naphthalene catabolic process	ISO Inferred from Sequence Orthology more info
involved_in naphthalene catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in trichloroethylene metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 2F2

Names: CYPIIF2; Cytochrome P450, subfamily IIF, polypeptide 1; P450-NAH-2; cytochrome P450, family 2, subfamily f, polypeptide 2; cytochrome P450, subfamily 2F, polypeptide 1; cytochrome P450-NAH-2; naphthalene dehydrogenase; naphthalene hydroxylase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.