U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Grp gastrin releasing peptide [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171101, updated on 9-Dec-2024

    Summary

    Official Symbol
    Grpprovided by RGD
    Official Full Name
    gastrin releasing peptideprovided by RGD
    Primary source
    RGD:621740
    See related
    EnsemblRapid:ENSRNOG00000016999 AllianceGenome:RGD:621740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable neuropeptide hormone activity. Involved in several processes, including cellular response to sodium phosphate; negative regulation of cation channel activity; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in extracellular space. Is active in neuronal dense core vesicle. Biomarker of chronic kidney disease. Orthologous to human GRP (gastrin releasing peptide). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 43.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Grp in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (61658655..61672037)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (59388679..59402061)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (61563458..61576818)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SEC11 homolog C, signal peptidase complex subunit Neighboring gene uncharacterized LOC134483043 Neighboring gene retina and anterior neural fold homeobox Neighboring gene complexin 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables neuropeptide hormone activity  
    enables neuropeptide hormone activity  
    Process Evidence Code Pubs
    involved_in cellular response to sodium phosphate PubMed 
    involved_in mast cell degranulation  
    involved_in mast cell degranulation  
    involved_in negative regulation of voltage-gated potassium channel activity PubMed 
    involved_in negative regulation of voltage-gated sodium channel activity PubMed 
    involved_in neuropeptide signaling pathway  
    involved_in neuropeptide signaling pathway PubMed 
    acts_upstream_of_or_within neuropeptide signaling pathway  
    involved_in ossification PubMed 
    involved_in positive regulation of behavioral fear response  
    involved_in positive regulation of behavioral fear response  
    involved_in positive regulation of peptide hormone secretion  
    involved_in positive regulation of peptide hormone secretion  
    involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in positive regulation of respiratory gaseous exchange  
    involved_in positive regulation of respiratory gaseous exchange  
    involved_in positive regulation of vascular associated smooth muscle cell apoptotic process PubMed 
    involved_in psychomotor behavior  
    involved_in regulation of gene expression PubMed 
    involved_in response to external biotic stimulus  
    involved_in social behavior  
    Component Evidence Code Pubs
    located_in extracellular region PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in extracellular space  
    located_in neuron projection  
    located_in neuron projection  
    is_active_in neuronal dense core vesicle PubMed 
    located_in secretory granule lumen  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133570.5NP_598254.2  gastrin-releasing peptide preproprotein

      See identical proteins and their annotated locations for NP_598254.2

      Status: VALIDATED

      Source sequence(s)
      AW524119, BF567195, JAXUCZ010000018
      UniProtKB/Swiss-Prot
      G3V871, P24393
      Related
      ENSRNOP00000022845.1, ENSRNOT00000022845.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      61658655..61672037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.