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    Lpar3 lysophosphatidic acid receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66025, updated on 9-Dec-2024

    Summary

    Symbol
    Lpar3provided by RGD
    Full Name
    lysophosphatidic acid receptor 3provided by RGD
    Primary source
    RGD:620565
    See related
    EnsemblRapid:ENSRNOG00000064204 AllianceGenome:RGD:620565
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Edg7
    Summary
    Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of calcium ion transport. Predicted to be located in axon. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 59.9), Lung (RPKM 38.6) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lpar3 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (237785371..237854199)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235125234..235193916)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252090634..252159221)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mucolipin TRP cation channel 3 Neighboring gene dynein axonemal intermediate chain 3 Neighboring gene mucolipin TRP cation channel 2 Neighboring gene RNA, U6 small nuclear 777 Neighboring gene SSX family member 2 interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in bleb assembly  
    acts_upstream_of_or_within bleb assembly  
    involved_in collateral sprouting  
    acts_upstream_of collateral sprouting  
    involved_in gene expression  
    involved_in gene expression  
    involved_in positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of MAPK cascade  
    involved_in positive regulation of calcium ion transport PubMed 
    involved_in positive regulation of collateral sprouting  
    acts_upstream_of_or_within positive regulation of collateral sprouting  
    involved_in regulation of metabolic process  
    Component Evidence Code Pubs
    located_in axon  
    located_in axon  
    is_active_in cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    lysophosphatidic acid receptor 3
    Names
    LPA receptor 3
    LPA-3
    endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7
    lysophosphatidic acid receptor Edg-7
    putative G protein-coupled receptor snGPCR32
    snGPCR32

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023969.2NP_076459.2  lysophosphatidic acid receptor 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6A9K7
      Conserved Domains (1) summary
      cd15343
      Location:22295
      7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      237785371..237854199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233470.5XP_006233532.1  lysophosphatidic acid receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006233532.1

      UniProtKB/Swiss-Prot
      Q8K5E0, Q9ESJ6
      UniProtKB/TrEMBL
      A6HWD3
      Conserved Domains (1) summary
      cd15343
      Location:31304
      7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_006233469.5XP_006233531.1  lysophosphatidic acid receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006233531.1

      UniProtKB/Swiss-Prot
      Q8K5E0, Q9ESJ6
      UniProtKB/TrEMBL
      A6HWD3
      Related
      ENSRNOP00000089155.2, ENSRNOT00000112864.2
      Conserved Domains (1) summary
      cd15343
      Location:31304
      7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_039103115.1XP_038959043.1  lysophosphatidic acid receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8K5E0, Q9ESJ6
      UniProtKB/TrEMBL
      A6HWD3
      Conserved Domains (1) summary
      cd15343
      Location:31304
      7tmA_LPAR3_Edg7; lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors
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