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    Chm CHM Rab escort protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24942, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chmprovided by RGD
    Official Full Name
    CHM Rab escort proteinprovided by RGD
    Primary source
    RGD:2340
    See related
    EnsemblRapid:ENSRNOG00000000161 AllianceGenome:RGD:2340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables small GTPase binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Human ortholog(s) of this gene implicated in choroideremia. Orthologous to human CHM (CHM Rab escort protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 114.1), Kidney (RPKM 95.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Chm in Genome Data Viewer
    Location:
    Xq31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (82395463..82554249, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (78203200..78361996, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (84666900..84821775, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932431L22 gene like Neighboring gene uncharacterized LOC134484138 Neighboring gene uncharacterized LOC134484103 Neighboring gene tubulin, gamma 1, pseudogene 1 Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA 361 Neighboring gene U4 spliceosomal RNA Neighboring gene dachshund family transcription factor 2 Neighboring gene small nucleolar RNA SNORA31

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity  
    enables GTPase activator activity  
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables small GTPase binding PubMed 
    enables small GTPase binding  
    enables small GTPase binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development  
    involved_in intracellular protein transport  
    involved_in protein geranylgeranylation PubMed 
    involved_in protein geranylgeranylation  
    involved_in protein geranylgeranylation  
    involved_in protein targeting to membrane  
    involved_in protein targeting to membrane  
    involved_in protein targeting to membrane  
    involved_in small GTPase-mediated signal transduction  
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex  
    part_of Rab-protein geranylgeranyltransferase complex PubMed 
    part_of Rab-protein geranylgeranyltransferase complex  
    part_of Rab-protein geranylgeranyltransferase complex PubMed 
    part_of Rab-protein geranylgeranyltransferase complex  
    part_of Rab-protein geranylgeranyltransferase complex  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleus  

    General protein information

    Preferred Names
    rab proteins geranylgeranyltransferase component A 1
    Names
    CHM, Rab escort protein 1
    REP-1
    choroideraemia protein homolog
    choroideremia (Rab escort protein 1)
    choroideremia protein homolog
    choroidermia
    rab escort protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433732.1NP_001420661.1  rab proteins geranylgeranyltransferase component A 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6AG68
    2. NM_017067.2NP_058763.2  rab proteins geranylgeranyltransferase component A 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P37727
      UniProtKB/TrEMBL
      A6IVA7, G3V607
      Related
      ENSRNOP00000000174.7, ENSRNOT00000000174.9

    RNA

    1. NR_197594.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      82395463..82554249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099489.2XP_038955417.1  rab proteins geranylgeranyltransferase component A 1 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:149457
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_005497922.1 RNA Sequence

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