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    Hmgn2 high mobility group nucleosomal binding domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114637, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hmgn2provided by RGD
    Official Full Name
    high mobility group nucleosomal binding domain 2provided by RGD
    Primary source
    RGD:620649
    See related
    EnsemblRapid:ENSRNOG00000051615 AllianceGenome:RGD:620649
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hmg17
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and chromatin organization. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and regulation of development, heterochronic. Predicted to be located in cytoplasm; extracellular space; and female germ cell nucleus. Predicted to be active in nucleus. Orthologous to human HMGN2 (high mobility group nucleosomal binding domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 1733.5), Adrenal (RPKM 758.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hmgn2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151475907..151479361, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146192126..146195580, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152195359..152198813, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3 like 9 Neighboring gene ribosomal protein L37A like 3 Neighboring gene dehydrodolichyl diphosphate synthase subunit Neighboring gene lin-28 homolog A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC116347, MGC124667

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding  
    enables nucleosomal DNA binding  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromosome PubMed 
    located_in cytoplasm  
    located_in extracellular space  
    located_in female germ cell nucleus  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    non-histone chromosomal protein HMG-17
    Names
    high mobility group nucleosome binding domain 2
    high mobility group nucleosome-binding domain-containing protein 2
    high mobility group protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025624.2NP_001020795.1  non-histone chromosomal protein HMG-17

      See identical proteins and their annotated locations for NP_001020795.1

      Status: VALIDATED

      Source sequence(s)
      BC099815, CB614313
      UniProtKB/Swiss-Prot
      P18437
      UniProtKB/TrEMBL
      A6ISZ1, A6ISZ2, Q4KLJ0
      Related
      ENSRNOP00000082813.2, ENSRNOT00000095450.2
      Conserved Domains (1) summary
      pfam01101
      Location:188
      HMG14_17; HMG14 and HMG17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      151475907..151479361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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