Nynrin NYN domain and retroviral integrase containing [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nynrinprovided by RGD
Official Full Name: NYN domain and retroviral integrase containingprovided by RGD
Primary source: RGD:6486974
See related: EnsemblRapid:ENSRNOG00000048431 AllianceGenome:RGD:6486974
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA integration. Orthologous to human NYNRIN (NYN domain and retroviral integrase containing). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 64.6), Kidney (RPKM 47.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33302778..33325120)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29332873..29355215)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34520040..34541671)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA-DNA hybrid ribonuclease activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA integration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NYN domain and retroviral integrase containing; protein NYNRIN

Names: protein NYNRIN-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433131.1 → NP_001420060.1 NYN domain and retroviral integrase containing

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

M0RAC3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

33302778..33325120

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093836.2 → XP_038949764.1 protein NYNRIN

Related

ENSRNOP00000066468.3, ENSRNOT00000074659.4

Conserved Domains (6) summary

cd18728
Location:802 → 926

PIN_N4BP1-like; PRORP-like PIN domain of NEDD4 binding protein 1 and related proteins

pfam17919
Location:1136 → 1236

RT_RNaseH_2; RNase H-like domain found in reverse transcriptase

pfam17921
Location:1542 → 1599

Integrase_H2C2; Integrase zinc binding domain

NF033913
Location:545 → 692

fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

cd09032
Location:12 → 73

KH-I_N4BP1_like_rpt1; first type I K homology (KH) RNA-binding domain found in the family of NEDD4-binding protein 1 (N4BP1)

cd22477
Location:75 → 140

KH-I_NYNRIN_like; type I K homology (KH) RNA-binding domain found in the subfamily of NYN domain and retroviral integrase catalytic domain-containing protein (NYNRIN)