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    Pgap3 post-GPI attachment to proteins phospholipase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgap3provided by RGD
    Official Full Name
    post-GPI attachment to proteins phospholipase 3provided by RGD
    Primary source
    RGD:1592386
    See related
    EnsemblRapid:ENSRNOG00000046143 AllianceGenome:RGD:1592386
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Perld1
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 4. Orthologous to human PGAP3 (post-GPI attachment to proteins phospholipase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 38.5), Heart (RPKM 23.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pgap3 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83883406..83895408, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83387113..83399357, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86343058..86356146, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene titin-cap Neighboring gene phenylethanolamine-N-methyltransferase Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene migration and invasion enhancer 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the CAB2/hCOS16 gene required for the repair of DNA double-strand breaks on a core amplified region of the 17q12 locus in breast and gastric cancers. Nezu M, et al. Jpn J Cancer Res, 2002 Nov. PMID 12460457, Free PMC Article
    2. PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins. Fujita M, et al. Mol Biol Cell, 2006 Dec. PMID 17021251, Free PMC Article
    3. Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Hirata T, et al. Nat Commun, 2018 Jan 26. PMID 29374258, Free PMC Article
    4. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187648

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    post-GPI attachment to proteins factor 3
    Names
    per1-like domain containing 1
    post-GPI attachment to proteins 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143895.1 → NP_001137367.1  post-GPI attachment to proteins factor 3 precursor

      See identical proteins and their annotated locations for NP_001137367.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HIS2, B1WBW5, M0R5R1
      Related
      ENSRNOP00000064738.2, ENSRNOT00000075076.4
      Conserved Domains (1) summary
      pfam04080
      Location:54 → 305
      Per1; Per1-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83883406..83895408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768113.4 → XP_008766335.1  post-GPI attachment to proteins factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A827
      Related
      ENSRNOP00000087841.1, ENSRNOT00000119078.2
      Conserved Domains (1) summary
      pfam04080
      Location:54 → 255
      Per1; Per1-like
    Nucleotide Protein Strain
    Heading Accession and Version

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