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    Leprotl1 leptin receptor overlapping transcript-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361160, updated on 9-Dec-2024

    Summary

    Official Symbol
    Leprotl1provided by RGD
    Official Full Name
    leptin receptor overlapping transcript-like 1provided by RGD
    Primary source
    RGD:1307168
    See related
    EnsemblRapid:ENSRNOG00000012601 AllianceGenome:RGD:1307168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and negative regulation of growth hormone receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endosome. Orthologous to human LEPROTL1 (leptin receptor overlapping transcript like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 216.8), Lung (RPKM 171.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Leprotl1 in Genome Data Viewer
    Location:
    16q12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (64744148..64756776)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (58040934..58053602)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (61758941..61769655)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene store-operated calcium entry-associated regulatory factor Neighboring gene uncharacterized LOC134482511 Neighboring gene uncharacterized LOC134482512 Neighboring gene membrane bound O-acyltransferase domain containing 4 Neighboring gene dynactin subunit 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in endosome  
    located_in membrane  

    General protein information

    Preferred Names
    leptin receptor overlapping transcript-like 1
    Names
    endospanin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013188.3NP_001013206.1  leptin receptor overlapping transcript-like 1

      See identical proteins and their annotated locations for NP_001013206.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q6PDU4
      UniProtKB/TrEMBL
      A0A8I6AQM0
      Related
      ENSRNOP00000112524.1, ENSRNOT00000123298.1
      Conserved Domains (1) summary
      pfam04133
      Location:7124
      Vps55; Vacuolar protein sorting 55

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      64744148..64756776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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